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    Cdh17 cadherin 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117048, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdh17provided by RGD
    Official Full Name
    cadherin 17provided by RGD
    Primary source
    RGD:619748
    See related
    EnsemblRapid:ENSRNOG00000015562 AllianceGenome:RGD:619748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-catenin binding activity; cell adhesion molecule binding activity; and proton-dependent oligopeptide secondary active transmembrane transporter activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cell-cell junction organization; and mature B cell differentiation involved in immune response. Located in basolateral plasma membrane. Orthologous to human CDH17 (cadherin 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 60.2), Adrenal (RPKM 22.0) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdh17 in Genome Data Viewer
    Location:
    5q13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (30024544..30112226)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (25262820..25314884)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (25354187..25443675)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552309 Neighboring gene GTP binding protein overexpressed in skeletal muscle Neighboring gene uncharacterized LOC102552377 Neighboring gene uncharacterized LOC134478935 Neighboring gene pyruvate dehydrogenase phosphatase catalytic subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proton-dependent oligopeptide secondary active transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables proton-dependent oligopeptide secondary active transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adherens junction organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in germinal center B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in marginal zone B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligopeptide transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within oligopeptide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligopeptide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catenin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cadherin-17
    Names
    LI-cadherin
    liver-intestine cadherin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053977.2NP_446429.1  cadherin-17 precursor

      See identical proteins and their annotated locations for NP_446429.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005, X78997
      UniProtKB/Swiss-Prot
      P55281
      UniProtKB/TrEMBL
      A0A8I6ANM1, A6II73
      Related
      ENSRNOP00000021612.2, ENSRNOT00000021612.6
      Conserved Domains (1) summary
      cd11304
      Location:569662
      Cadherin_repeat; Cadherin tandem repeat domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      30024544..30112226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287080.1XP_063143150.1  cadherin-17 isoform X2

      UniProtKB/Swiss-Prot
      P55281
      UniProtKB/TrEMBL
      A0A8I6ANM1, A6II73
    2. XM_063287082.1XP_063143152.1  cadherin-17 isoform X2

      UniProtKB/Swiss-Prot
      P55281
      UniProtKB/TrEMBL
      A0A8I6ANM1, A6II73
    3. XM_063287081.1XP_063143151.1  cadherin-17 isoform X2

      UniProtKB/Swiss-Prot
      P55281
      UniProtKB/TrEMBL
      A0A8I6ANM1, A6II73
    4. XM_039109161.2XP_038965089.2  cadherin-17 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZV9
      Related
      ENSRNOP00000084699.2, ENSRNOT00000095525.2
    5. XM_063287079.1XP_063143149.1  cadherin-17 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZV9
    6. XM_063287083.1XP_063143153.1  cadherin-17 isoform X3