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    CT45A10 cancer/testis antigen family 45 member A10 [ Homo sapiens (human) ]

    Gene ID: 102723631, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CT45A10provided by HGNC
    Official Full Name
    cancer/testis antigen family 45 member A10provided by HGNC
    Primary source
    HGNC:HGNC:51263
    See related
    Ensembl:ENSG00000269586 AllianceGenome:HGNC:51263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT45-5; CT45A5
    Summary
    Enables identical protein binding activity. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis (RPKM 7.2) See more
    Orthologs
    all
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    Genomic context

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    See CT45A10 in Genome Data Viewer
    Location:
    Xq26.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (135881065..135893444, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (134189395..134201774, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134963215..134975595, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen family 45 member A8 Neighboring gene cancer/testis antigen family 45 member A9 Neighboring gene Sharpr-MPRA regulatory region 13624 Neighboring gene sarcoma antigen 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:134987035-134988234 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:135014477-135014713 Neighboring gene cancer/testis antigen family 45 member A11, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen YT, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905330, Free PMC Article
    2. DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC. Wang Y, et al. Nat Commun, 2023 Apr 27. PMID 37105989, Free PMC Article
    3. GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer. Shin EM, et al. Sci Adv, 2021 Mar. PMID 33731348, Free PMC Article
    4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
    5. The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation. Gu X, et al. Science, 2023 Aug 25. PMID 37616343, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ78398, MGC88118, MGC177967, MGC177968, MGC178071, MGC178072

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cancer/testis antigen family 45 member A10
    Names
    Cancer/testis antigen 45-5
    Cancer/testis antigen 45A10
    Cancer/testis antigen 45A5
    Cancer/testis antigen family 45 member A5
    cancer/testis antigen family 45 member A-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291527.2 → NP_001278456.1  cancer/testis antigen family 45 member A10

      See identical proteins and their annotated locations for NP_001278456.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    2. NM_001291528.2 → NP_001278457.1  cancer/testis antigen family 45 member A10

      See identical proteins and their annotated locations for NP_001278457.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Related
      ENSP00000484601.1, ENST00000611668.4
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    3. NM_001291529.2 → NP_001278458.1  cancer/testis antigen family 45 member A10

      See identical proteins and their annotated locations for NP_001278458.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Related
      ENSP00000507965.1, ENST00000682849.1
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    4. NM_001291530.2 → NP_001278459.1  cancer/testis antigen family 45 member A10

      See identical proteins and their annotated locations for NP_001278459.1

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    5. NM_001385219.1 → NP_001372148.1  cancer/testis antigen family 45 member A10

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    6. NM_001385220.1 → NP_001372149.1  cancer/testis antigen family 45 member A10

      Status: VALIDATED

      Source sequence(s)
      AC240441
      Consensus CDS
      CCDS76035.1
      UniProtKB/Swiss-Prot
      A8K842, B7ZMC5, P0DMU9, Q6NSH3
      Conserved Domains (1) summary
      pfam15300
      Location:122 → 183
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      135881065..135893444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      134189395..134201774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMU9.1 GenPept UniProtKB/Swiss-Prot:P0DMU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials