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    Pdp2 pyruvate dehydrogenase phosphatase catalytic subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdp2provided by RGD
    Official Full Name
    pyruvate dehydrogenase phosphatase catalytic subunit 2provided by RGD
    Primary source
    RGD:628812
    See related
    EnsemblRapid:ENSRNOG00000012343 AllianceGenome:RGD:628812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Involved in peptidyl-threonine dephosphorylation and response to starvation. Located in mitochondrion. Orthologous to human PDP2 (pyruvate dehydrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 376.4), Liver (RPKM 172.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pdp2 in Genome Data Viewer
    Location:
    19p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (392858..400529, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (386408..394068, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (597427..601556, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene cadherin 16 Neighboring gene uncharacterized LOC120098574 Neighboring gene uncharacterized LOC134483518 Neighboring gene carbonic anhydrase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney. Huang B, et al. Diabetes, 2003 Jun. PMID 12765946, Free PMC Article
    2. Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation. Huang B, et al. J Biol Chem, 1998 Jul 10. PMID 9651365
    3. Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer. Roche TE, et al. Cell Mol Life Sci, 2007 Apr. PMID 17310282, Free PMC Article
    4. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Voss M, et al. Cell Signal, 2011 Jan. PMID 20801214
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Starvation and diabetes reduce the amount of this enzyme in heart and kidney.
      Title: Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T-helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial
    Names
    PDP 2
    PDPC 2
    pyruvate dehydrogenase phosphatase isoenzyme 2
    pyruvate dehyrogenase phosphatase catalytic subunit 2
    NP_659559.2
    XP_006255110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145091.4 → NP_659559.2  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_659559.2

      Status: VALIDATED

      Source sequence(s)
      BC072485
      UniProtKB/Swiss-Prot
      A0A0G2JSL7, O88484, Q6IN27
      UniProtKB/TrEMBL
      A6JXU9
      Conserved Domains (1) summary
      smart00332
      Location:96 → 516
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      392858..400529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255048.5 → XP_006255110.1  pyruvate dehydrogenase [acetyl-transferring]-phosphatase 2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006255110.1

      UniProtKB/Swiss-Prot
      A0A0G2JSL7, O88484, Q6IN27
      UniProtKB/TrEMBL
      A6JXU9
      Related
      ENSRNOP00000112807.1, ENSRNOT00000156966.1
      Conserved Domains (1) summary
      smart00332
      Location:96 → 516
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88484.2 GenPept UniProtKB/Swiss-Prot:O88484

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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