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    Cd209c CD209c antigen [ Mus musculus (house mouse) ]

    Gene ID: 170776, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cd209cprovided by MGI
    Official Full Name
    CD209c antigenprovided by MGI
    Primary source
    MGI:MGI:2157945
    See related
    Ensembl:ENSMUSG00000040165 AllianceGenome:MGI:2157945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SIGNR2; mSIGNR2
    Summary
    Enables D-mannose binding activity. Predicted to be involved in several processes, including B cell adhesion; positive regulation of T cell proliferation; and positive regulation of viral life cycle. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease; aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to human CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Cd209c in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3990081..4004746, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3940081..3954746, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20600 Neighboring gene CD209d antigen Neighboring gene STARR-seq mESC enhancer starr_20601 Neighboring gene CD209b antigen Neighboring gene predicted gene, 39122 Neighboring gene exportin, tRNA (nuclear export receptor for tRNAs) pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Park CG, et al. Int Immunol, 2001 Oct. PMID 11581173
    2. Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. Hoffmann D, et al. EMBO J, 2021 Oct 1. PMID 34375000, Free PMC Article
    3. Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins. Powlesland AS, et al. J Biol Chem, 2006 Jul 21. PMID 16682406
    4. Comparative human-mouse-rat sequence analysis of the ICAM gene cluster on HSA 19p13.2 and a 185-kb porcine region from SSC 2q. Leeb T, et al. Gene, 2004 Dec 22. PMID 15588578
    5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-mannose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of viral life cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in symbiont entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CD209 antigen-like protein C
    Names
    DC-SIGN-related protein 2
    DC-SIGNR2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130903.4 → NP_570973.1  CD209 antigen-like protein C

      See identical proteins and their annotated locations for NP_570973.1

      Status: VALIDATED

      Source sequence(s)
      AC121948
      Consensus CDS
      CCDS22078.1
      UniProtKB/Swiss-Prot
      Q0VB37, Q91ZW9
      Related
      ENSMUSP00000039861.8, ENSMUST00000044060.14
      Conserved Domains (1) summary
      cd03590
      Location:48 → 170
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3990081..4004746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312590.1 → XP_017168079.1  CD209 antigen-like protein C isoform X2

      Conserved Domains (1) summary
      cd03590
      Location:81 → 203
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    2. XM_017312589.1 → XP_017168078.1  CD209 antigen-like protein C isoform X1

      Conserved Domains (1) summary
      cd03590
      Location:110 → 232
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    3. XM_006508705.2 → XP_006508768.1  CD209 antigen-like protein C isoform X4

      Conserved Domains (1) summary
      cd03590
      Location:15 → 137
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    4. XM_006508704.2 → XP_006508767.1  CD209 antigen-like protein C isoform X3

      Conserved Domains (1) summary
      cd03590
      Location:38 → 160
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    RNA

    1. XR_003947240.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZW9.1 GenPept UniProtKB/Swiss-Prot:Q91ZW9

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