Kcnk1 potassium channel, subfamily K, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnk1provided by MGI
Official Full Name: potassium channel, subfamily K, member 1provided by MGI
Primary source: MGI:MGI:109322
See related: Ensembl:ENSMUSG00000033998 AllianceGenome:MGI:109322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TWIK-1
Summary: Enables identical protein binding activity; protein heterodimerization activity; and voltage-gated monoatomic ion channel activity. Involved in chloride transmembrane transport; glutamate secretion; and potassium ion transmembrane transport. Located in endosome and plasma membrane. Part of inward rectifier potassium channel complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KCNK1 (potassium two pore domain channel subfamily K member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in genital fat pad adult (RPKM 45.9), cerebellum adult (RPKM 26.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E2; 8 73.67 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (126718692..126757424)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (125993655..126030685)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

beta-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
Title: β-COP Regulates TWIK1/TREK1 Heterodimeric Channel-Mediated Passive Conductance in Astrocytes.
TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression.
Title: TWIK-1 BAC-GFP Transgenic Mice, an Animal Model for TWIK-1 Expression.
Findings suggest that DNA methyltransferase 3A (DNMT3a)-triggered downregulation of dorsal root ganglia (DRG) potassium channel subfamily K member 1 (KCNK1; K2p 1.1) may contribute to chemotherapy-induced neuropathic pain.
Title: DNMT3a-triggered downregulation of K(2p) 1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain.
results reveal the local conformational changes of the TWIK1 selectivity filter and suggest that the amide-I bands may be useful "molecular fingerprints" for assessing the properties of other K(+) channels
Title: Structural properties determining low K(+) affinity of the selectivity filter in the TWIK1 K(+) channel.
the activation of mGluR3 up-regulates the membrane expression of TWIK-1 that in turn enhances NH4(+) uptake in astrocytes.
Title: mGluR3 Activation Recruits Cytoplasmic TWIK-1 Channels to Membrane that Enhances Ammonium Uptake in Hippocampal Astrocytes.
KCNK1 was significantly induced during osteoclast differentiation, but its functional overexpression significantly inhibited osteoclast differentiation induced by RANKL
Title: KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK-NFATc1 signaling axis.
TWIK-1 is functionally expressed in dentate gyrus granule cells and contributes to the intrinsic excitability of these cells.
Title: TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus.
TWIK-1/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate release from astrocytes.
Title: A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes.
ion selectivity of TWIK-1 K+ channels during pathological hypokalemia; a molecular basis for inward leak Na+ currents that could trigger or contribute to cardiac paradoxical depolarization in lowered [K+]o; mechanism for regulating cardiac excitability.
Title: TWIK-1 two-pore domain potassium channels change ion selectivity and conduct inward leak sodium currents in hypokalemia.
Specifically localized in 'non-sensory' cells of inner ear, in dark cells of vestibule and in strial marginal cells of cochlea. May have role in regulation of K(+) homeostasis in dark cells and in strial marginal cells.
Title: Cellular localization of TWIK-1, a two-pore-domain potassium channel in the rodent inner ear.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236043

Kcnk1 (e-PCR), detects polymorphism
- UniSTS:255283

Kcnk1 (e-PCR), detects polymorphism
- UniSTS:143670

AI788889 (e-PCR)
- UniSTS:165612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables inward rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium ion leak channel activity	ISO Inferred from Sequence Orthology more info
enables potassium ion leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel activity	ISO Inferred from Sequence Orthology more info
enables sodium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glutamate secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IC Inferred by Curator more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of resting membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of resting membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of inward rectifier potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel subfamily K member 1

Names: inward rectifying potassium channel protein TWIK-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008430.2 → NP_032456.2 potassium channel subfamily K member 1

See identical proteins and their annotated locations for NP_032456.2

Status: VALIDATED

Source sequence(s)

AC102420, AF033017, AK137224, BG088333, BY240683

Consensus CDS

CCDS22783.1

UniProtKB/Swiss-Prot

O08581, Q99L99

Related

ENSMUSP00000046103.9, ENSMUST00000046765.10

Conserved Domains (1) summary

pfam07885
Location:100 → 157

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

126718692..126757424

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530716.4 → XP_006530779.1 potassium channel subfamily K member 1 isoform X1

UniProtKB/TrEMBL

A0A1D5RMH2

Related

ENSMUSP00000148778.2, ENSMUST00000212831.2

Conserved Domains (1) summary

pfam07885
Location:88 → 157

Ion_trans_2; Ion channel