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    LOC114574119 olfactory receptor enhancer Fourni [ Mus musculus (house mouse) ]

    Gene ID: 114574119, updated on 9-Aug-2024

    Summary

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    Gene symbol
    LOC114574119
    Gene description
    olfactory receptor enhancer Fourni
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rr366827
    Summary
    This genomic region represents one of several intergenic enhancers, known as Greek islands, which aggregate to form an interchromosomal hub that enables expression of a single olfactory receptor (OR) gene in olfactory sensory neurons. While all of the other OR gene clusters are sequestered in a large heterochromatic domain, this multi-enhancer interaction network evades heterochromatic silencing by associating with the transcription factors Lhx2 (LIM homeobox 2) and Ebf (EBF transcription factor), which bind in a functionally cooperative manner to allow expression of the active OR gene. The Greek island represented in this genomic region, Fourni, was validated as a functional enhancer by reporter assays in olfactory sensory neurons of transgenic zebrafish embyros. [provided by RefSeq, Apr 2019]
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    Genomic context

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    See LOC114574119 in Genome Data Viewer
    Location:
    chromosome: 7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139766521..139767338)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140186608..140187425)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily AE member 1 Neighboring gene STARR-seq mESC enhancer starr_20448 Neighboring gene olfactory receptor family 6 subfamily F member 2 Neighboring gene scavenger receptor family member expressed on T cells 1 Neighboring gene olfactory receptor family 6 subfamily B member 13 Neighboring gene scavenger receptor family member expressed on T cells 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromosomes come together to help mice distinguish odours. Spitz F. Nature, 2019 Jan. PMID 30666054
    2. Monoallelic expression of olfactory receptors. Monahan K, et al. Annu Rev Cell Dev Biol, 2015. PMID 26359778, Free PMC Article
    3. How keeping active pays off in the olfactory system. Monahan K, et al. Elife, 2012 Dec 13. PMID 23240088, Free PMC Article
    4. LHX2- and LDB1-mediated trans interactions regulate olfactory receptor choice. Monahan K, et al. Nature, 2019 Jan. PMID 30626972, Free PMC Article
    5. Cooperative interactions enable singular olfactory receptor expression in mouse olfactory neurons. Monahan K, et al. Elife, 2017 Sep 21. PMID 28933695, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Other Names

    • Fourni Greek island enhancer
    • regulatory region 366827

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_064635.1 

      Range
      101..918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139766521..139767338
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials