TNS2 tensin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNS2provided by HGNC
Official Full Name: tensin 2provided by HGNC
Primary source: HGNC:HGNC:19737
See related: Ensembl:ENSG00000111077 MIM:607717; AllianceGenome:HGNC:19737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C1TEN; TENC1; C1-TEN
Summary: The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 68.0), ovary (RPKM 31.0) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.13

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (53046991..53064379)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (53011375..53028746)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (53440775..53458163)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
Title: Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
Collectively,these findings suggest that the interaction between the C1-Ten/Tensin2 SH2 domain and PtdIns(3,4,5)P3 produces a negative feedback loop of insulin signaling through IRS-1.
Title: Cellular phosphatase activity of C1-Ten/Tensin2 is controlled by Phosphatidylinositol-3,4,5-triphosphate binding through the C1-Ten/Tensin2 SH2 domain.
Study observed significant increase in C1-Ten level in diabetic kidney and in high glucose-induced damaged podocytes. C1-Ten acts as a protein tyrosine phosphatase (PTPase) at the nephrin-PI3K binding site and renders PI3K for IRS-1, thereby activating mTORC1. These findings demonstrate the relationship between nephrin dephosphorylation and the mTORC1 pathway, mediated by C1-Ten PTPase activity.
Title: C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation.
Axl binds to and phosphorylates TNS2 and that Axl/TNS2/IRS-1 cross-talk may potentially play a critical role in glucose metabolism of cancer cells.
Title: AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells.
Patients with low TNS2 expression showed poor relapse-free survival rates for breast and lung cancers. These results strongly suggest a role of tensin2 in suppressing cell transformation and reduction of tumorigenicity.
Title: Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers.
p62 expression increased but C1-Ten protein decreased during muscle differentiation, supporting a role for p62 as a physiological regulator of C1-Ten.
Title: Regulation of C1-Ten protein tyrosine phosphatase by p62/SQSTM1-mediated sequestration and degradation.
Pulldown studies in human cells using Myc-tagged Tensin2 constructs revealed that DISC1 specifically interacts with the C-terminal PTB domain of Tensin2 in a phosphorylation-independent manner.
Title: Interaction of DISC1 with the PTB domain of Tensin2.
The tumor suppressor DLC1 utilizes a novel binding site for tensin2 PTB domain interaction
Title: Solution structure of the phosphotyrosine binding (PTB) domain of human tensin2 protein in complex with deleted in liver cancer 1 (DLC1) peptide reveals a novel peptide binding mode.
Results identified tensin2 as a Syk-binding protein.
Title: The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2.
Here, we report complete chemical shift assignments of the SH2 domain of human tensin2 determined by triple resonance experiments.
Title: 1H, 15N and 13C chemical shift assignments of the SH2 domain of human tensin2 (TENC1).

Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-21011 (e-PCR)
- UniSTS:38753

SHGC-156083 (e-PCR)
- UniSTS:182629

RH44510 (e-PCR)
- UniSTS:38306

BCD2163 (e-PCR)
- UniSTS:53418

RH48612 (e-PCR)
- UniSTS:63218

MARC_7649-7650:996688053:1 (e-PCR)
- UniSTS:269818

RH11261 (e-PCR)
- UniSTS:21499

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular homeostasis	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level homeostasis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tensin-2

Names: C1 domain-containing phosphatase and tensin homolog; tensin like C1 domain containing phosphatase (tensin 2); tensin-like C1 domain-containing phosphatase

NP_001403131.1

EC 3.1.3.48

NP_001403132.1

EC 3.1.3.48

NP_001403133.1

EC 3.1.3.48

NP_056134.3

EC 3.1.3.48

NP_736610.2

EC 3.1.3.48

NP_938072.1

EC 3.1.3.48

XP_016874577.1

EC 3.1.3.48

XP_016874578.1

EC 3.1.3.48

XP_047284560.1

EC 3.1.3.48

XP_054227544.1

EC 3.1.3.48

XP_054227545.1

EC 3.1.3.48

XP_054227546.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416202.1 → NP_001403131.1 tensin-2 isoform 4

Status: REVIEWED

Source sequence(s)

AC068888
NM_001416203.1 → NP_001403132.1 tensin-2 isoform 5

Status: REVIEWED

Source sequence(s)

AC068888
NM_001416204.1 → NP_001403133.1 tensin-2 isoform 6

Status: REVIEWED

Source sequence(s)

AC068888

Related

ENST00000549311.7
NM_015319.3 → NP_056134.3 tensin-2 isoform 1

Status: REVIEWED

Source sequence(s)

AC068888

Consensus CDS

CCDS8842.1

Related

ENSP00000319756.3, ENST00000314276.7
NM_170754.4 → NP_736610.2 tensin-2 isoform 2

See identical proteins and their annotated locations for NP_736610.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) has a distinct 5' UTR and coding region, compared to variant 1, resulting in a protein (isoform 2) that is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC068888, AF518729, BC054099, BX647126

Consensus CDS

CCDS8843.1

UniProtKB/Swiss-Prot

A2VDF2, A2VDF3, A2VDI8, A5PKY4, Q2NL80, Q63HR2, Q76MW6, Q7Z5T9, Q8NFF9, Q8NFG0, Q96P25, Q9NT29, Q9UPS7

UniProtKB/TrEMBL

A7E2A6

Related

ENSP00000319684.7, ENST00000314250.11

Conserved Domains (5) summary

cd09927
Location:1136 → 1249

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:189 → 309

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd00029
Location:32 → 79

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01213
Location:1273 → 1405

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:297 → 424

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
NM_198316.2 → NP_938072.1 tensin-2 isoform 3

See identical proteins and their annotated locations for NP_938072.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has a distinct 5' UTR and coding region, compared to variant 1, resulting in the use of a downstream translational start and a protein (isoform 3) that contains a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AF417490, AK131320, BC142712, BX442306

Consensus CDS

CCDS8844.1

UniProtKB/TrEMBL

A7E2A6

Related

ENSP00000369232.3, ENST00000379902.7

Conserved Domains (4) summary

cd09927
Location:1012 → 1125

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:65 → 185

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd01213
Location:1149 → 1281

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:173 → 300

PTEN_C2; C2 domain of PTEN tumour-suppressor protein