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    Kpc1 Kip1 ubiquitination-promoting complex subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kpc1provided by FlyBase
    Official Full Name
    Kip1 ubiquitination-promoting complex subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038296
    Locus tag
    Dmel_CG6752
    See related
    AllianceGenome:FB:FBgn0038296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6752; dKpc1; dKPC1; Dmel\CG6752
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in sperm flagellum. Part of ubiquitin ligase complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; organism; and ventral midline of embryo. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kpc1 in Genome Data Viewer
    Location:
    88E2-88E2; 3-56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15191058..15196210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11016780..11021932, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glycogen synthase Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea Neighboring gene Serpin 88Eb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility. Li W, et al. PLoS Genet, 2020 Dec. PMID 33378371, Free PMC Article
    2. OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress. Villa S, et al. Nat Commun, 2024 Aug 11. PMID 39127721, Free PMC Article
    3. MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Flynt AS, et al. Mol Cell, 2010 Jun 25. PMID 20620959, Free PMC Article
    4. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
    5. Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Kankel MW, et al. Genetics, 2020 Jul. PMID 32345615, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kip1 ubiquitination-promoting complex subunit 1
    Names
    CG6752-PA
    CG6752-PB
    Kpc1-PA
    Kpc1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15191058..15196210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142168.2 → NP_650425.1  Kip1 ubiquitination-promoting complex subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC4
      Related
      FBpp0082488
      Conserved Domains (2) summary
      pfam13920
      Location:1261 → 1309
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12882
      Location:122 → 249
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

    2. NM_001260187.1 → NP_001247116.1  Kip1 ubiquitination-promoting complex subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC4
      Conserved Domains (2) summary
      pfam13920
      Location:1261 → 1309
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12882
      Location:122 → 249
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZS1 Q8SZS1
    Q9VFC4 Q9VFC4

    Gene LinkOut

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