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    Adgrf2 adhesion G protein-coupled receptor F2 [ Mus musculus (house mouse) ]

    Gene ID: 435529, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgrf2provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F2provided by MGI
    Primary source
    MGI:MGI:2182728
    See related
    Ensembl:ENSMUSG00000057899 AllianceGenome:MGI:2182728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR20; Gpr111
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Is expressed in heart; lung; metanephros; skin; and spleen. Orthologous to human ADGRF2P (adhesion G protein-coupled receptor F2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Adgrf2 in Genome Data Viewer
    Location:
    17 B3; 17 19.66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43004919..43054646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42694028..42743753, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42562 Neighboring gene STARR-seq mESC enhancer starr_42563 Neighboring gene STARR-seq mESC enhancer starr_42564 Neighboring gene STARR-seq mESC enhancer starr_42565 Neighboring gene STARR-seq mESC enhancer starr_42566 Neighboring gene patched domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_42567 Neighboring gene STARR-seq mESC enhancer starr_42568 Neighboring gene STARR-seq mESC enhancer starr_42569 Neighboring gene opsin 5 Neighboring gene STARR-seq mESC enhancer starr_42570 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene STARR-positive B cell enhancer mm9_chr17:42919148-42919448 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene CD2-associated protein Neighboring gene STARR-seq mESC enhancer starr_42571 Neighboring gene STARR-positive B cell enhancer ABC_E9167 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43024432-43024732 Neighboring gene STARR-seq mESC enhancer starr_42574 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43080467-43080767 Neighboring gene STARR-seq mESC enhancer starr_42577 Neighboring gene STARR-seq mESC enhancer starr_42579 Neighboring gene STARR-seq mESC enhancer starr_42581 Neighboring gene STARR-seq mESC enhancer starr_42583 Neighboring gene tumor necrosis factor receptor superfamily, member 21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process. Chiba Y, et al. FASEB J, 2023 Apr. PMID 36929047
    2. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Prömel S, et al. Dev Dyn, 2012 Oct. PMID 22837050
    3. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    4. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    5. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process.
      Title: Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor F2
    Names
    G protein coupled receptor Gpr111
    G protein-coupled receptor 111
    G protein-coupled receptor PGR20
    probable G-protein coupled receptor 111

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033493.2 → NP_001028665.2  adhesion G-protein coupled receptor F2 precursor

      See identical proteins and their annotated locations for NP_001028665.2

      Status: VALIDATED

      Source sequence(s)
      AC117257, AK142836, BB662982
      Consensus CDS
      CCDS28792.2
      UniProtKB/Swiss-Prot
      B9EJ67, E9Q4J9
      Related
      ENSMUSP00000109244.3, ENSMUST00000113614.3
      Conserved Domains (2) summary
      cl02559
      Location:326 → 373
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:380 → 624
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43004919..43054646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317565.2 → XP_017173054.1  adhesion G-protein coupled receptor F2 isoform X1

      UniProtKB/TrEMBL
      A0A668KM90
      Related
      ENSMUSP00000159259.2, ENSMUST00000239223.2
      Conserved Domains (2) summary
      cd15994
      Location:378 → 644
      7tmB2_GPR111_115; orphan adhesion receptors GPR111 and GPR115, member of the class B2 family of seven-transmembrane G protein-coupled receptors
      cl02559
      Location:326 → 373
      GPS; GPCR proteolysis site, GPS, motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q4J9.1 GenPept UniProtKB/Swiss-Prot:E9Q4J9

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