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    TRIM48 tripartite motif containing 48 [ Homo sapiens (human) ]

    Gene ID: 79097, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRIM48provided by HGNC
    Official Full Name
    tripartite motif containing 48provided by HGNC
    Primary source
    HGNC:HGNC:19021
    See related
    Ensembl:ENSG00000150244 AllianceGenome:HGNC:19021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF101
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See TRIM48 in Genome Data Viewer
    Location:
    11q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (55262155..55271114)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (55199727..55208688)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (55029631..55038590)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 4 subfamily A member 5 Neighboring gene olfactory receptor family 4 subfamily A member 6 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:54928734-54929283 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:54990100-54990612 Neighboring gene NANOG hESC enhancer GRCh37_chr11:55007108-55007609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:55008490-55009029 Neighboring gene NANOG hESC enhancer GRCh37_chr11:55019280-55019781 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:55025437-55026053 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:55026072-55026647 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:55026708-55027249 Neighboring gene tripartite motif containing 48 pseudogene Neighboring gene tripartite motif-containing 51H, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC4827

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM48
    Names
    RING finger protein 101
    tripartite motif-containing protein 48
    NP_077019.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024114.5NP_077019.2  E3 ubiquitin-protein ligase TRIM48

      See identical proteins and their annotated locations for NP_077019.2

      Status: VALIDATED

      Source sequence(s)
      AP005597, BC001862
      Consensus CDS
      CCDS7947.2
      UniProtKB/Swiss-Prot
      Q8IWZ4, Q9BUW4
      Related
      ENSP00000402414.2, ENST00000417545.5
      Conserved Domains (1) summary
      cl17238
      Location:3161
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      55262155..55271114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      55199727..55208688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)