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    Entpd6 ectonucleoside triphosphate diphosphohydrolase 6 [ Mus musculus (house mouse) ]

    Gene ID: 12497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Entpd6provided by MGI
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 6provided by MGI
    Primary source
    MGI:MGI:1202295
    See related
    Ensembl:ENSMUSG00000033068 AllianceGenome:MGI:1202295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd39l2; NTPDase-6; 2700026H11Rik
    Summary
    Predicted to enable pyrophosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process; response to calcium ion; and response to magnesium ion. Predicted to be located in cell surface; extracellular space; and plasma membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 27.5), genital fat pad adult (RPKM 15.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Entpd6 in Genome Data Viewer
    Location:
    2 G3; 2 74.74 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (150590959..150613595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (150748980..150771675)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase short-chain family member 1 Neighboring gene RIKEN cDNA E130215H24 gene Neighboring gene STARR-positive B cell enhancer ABC_E4509 Neighboring gene STARR-seq mESC enhancer starr_06014 Neighboring gene visual system homeobox 1 Neighboring gene STARR-positive B cell enhancer ABC_E2053 Neighboring gene STARR-positive B cell enhancer ABC_E1604 Neighboring gene STARR-positive B cell enhancer ABC_E11166 Neighboring gene predicted gene, 30141 Neighboring gene predicted gene, 57834 Neighboring gene brain glycogen phosphorylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and chromosomal mapping of a mouse gene with homology to NTPases. Chadwick BP, et al. Mamm Genome, 1998 Feb. PMID 9457681
    2. The CD39-like gene family: identification of three new human members (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the gene family from Drosophila melanogaster. Chadwick BP, et al. Genomics, 1998 Jun 15. PMID 9676430
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables CDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables IDP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables IDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 6
    Names
    CD39 antigen-like 2
    NTPDase 6
    NP_001341997.1
    NP_001357558.1
    NP_001357559.1
    NP_001357560.1
    NP_742115.2
    XP_017170703.1
    XP_030102887.1
    XP_030102889.1
    XP_030102891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355068.1 → NP_001341997.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845174
      Consensus CDS
      CCDS16861.1
      UniProtKB/Swiss-Prot
      Q3U0P5
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. NM_001370629.1 → NP_001357558.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001370630.1 → NP_001357559.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71 → 424
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. NM_001370631.1 → NP_001357560.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL845174
      Conserved Domains (1) summary
      cl17037
      Location:71 → 207
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    5. NM_172117.5 → NP_742115.2  ectonucleoside triphosphate diphosphohydrolase 6 isoform 1

      See identical proteins and their annotated locations for NP_742115.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL845174
      Consensus CDS
      CCDS16861.1
      UniProtKB/Swiss-Prot
      Q3U0P5
      Related
      ENSMUSP00000092038.6, ENSMUST00000094467.6
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      150590959..150613595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247031.2 → XP_030102891.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1 → 228
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_017315214.3 → XP_017170703.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X2

      Conserved Domains (1) summary
      cl17037
      Location:1 → 228
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_030247029.1 → XP_030102889.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0P5
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    4. XM_030247027.2 → XP_030102887.1  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0P5
      Conserved Domains (1) summary
      cl17037
      Location:71 → 448
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RNA

    1. XR_003950191.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0P5.1 GenPept UniProtKB/Swiss-Prot:Q3U0P5

    Gene LinkOut

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