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    PURB purine rich element binding protein B [ Homo sapiens (human) ]

    Gene ID: 5814, updated on 10-Dec-2024

    Summary

    Official Symbol
    PURBprovided by HGNC
    Official Full Name
    purine rich element binding protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:9702
    See related
    Ensembl:ENSG00000146676 MIM:608887; AllianceGenome:HGNC:9702
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PURBETA
    Summary
    This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. [provided by RefSeq, Jul 2008]
    Orthologs
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    Genomic context

    See PURB in Genome Data Viewer
    Location:
    7p13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44876299..44885530, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (45036709..45045943, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44915898..44925129, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44887269-44887826 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44887827-44888385 Neighboring gene H2AZ2 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 12861 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44924201-44925160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25957 Neighboring gene microRNA 4657 Neighboring gene uncharacterized LOC105375262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951201-44951702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44951703-44952202 Neighboring gene mitochondrial ribosomal protein S23 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, purine-rich element binding protein B (PURB), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PURB is increased by RRE PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126784, MGC126786

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding HDA PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SMAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA regulatory element binding translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables purine-rich negative regulatory element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables purine-rich negative regulatory element binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of myeloid cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transcriptional regulator protein Pur-beta
    Names
    transcriptional activator protein Pur-beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033224.5NP_150093.1  transcriptional regulator protein Pur-beta

      See identical proteins and their annotated locations for NP_150093.1

      Status: REVIEWED

      Source sequence(s)
      AC004854
      Consensus CDS
      CCDS5499.1
      UniProtKB/Swiss-Prot
      A4D2L7, Q96QR8
      Related
      ENSP00000379051.2, ENST00000395699.5
      Conserved Domains (1) summary
      pfam04845
      Location:31279
      PurA; PurA ssDNA and RNA-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      44876299..44885530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      45036709..45045943 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)