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    Letm2 leucine zipper-EF-hand containing transmembrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 270035, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Letm2provided by MGI
    Official Full Name
    leucine zipper-EF-hand containing transmembrane protein 2provided by MGI
    Primary source
    MGI:MGI:2444979
    See related
    Ensembl:ENSMUSG00000037363 AllianceGenome:MGI:2444979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030453H13; D030041N04Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM2 (leucine zipper and EF-hand containing transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 17.6), cerebellum adult (RPKM 2.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Letm2 in Genome Data Viewer
    Location:
    8 A2; 8 14.17 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26068494..26088005, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25578478..25597989, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31288 Neighboring gene fibroblast growth factor receptor 1 Neighboring gene VISTA enhancer mm612 Neighboring gene STARR-seq mESC enhancer starr_20978 Neighboring gene predicted gene 16159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26686963-26687146 Neighboring gene STARR-positive B cell enhancer ABC_E8232 Neighboring gene STARR-positive B cell enhancer ABC_E2860 Neighboring gene STARR-positive B cell enhancer ABC_E6630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26722454-26722679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26728550-26728737 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26830817-26831000 Neighboring gene phospholipid phosphatase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LETM1 domain-containing protein LETM2, mitochondrial
    Names
    LETM1 and EF-hand domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364069.1 → NP_001350998.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AW048776, BC055685, BE648035, DV647889
      Consensus CDS
      CCDS52527.1
      UniProtKB/Swiss-Prot
      Q7TNU7
      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    2. NM_001364070.1 → NP_001350999.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156990, AW048776, BC055685, BE648035
      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    3. NM_001364071.1 → NP_001351000.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC156990, AW048776, BC055685, BE648035, CJ087333
      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    4. NM_173012.3 → NP_766600.2  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AW048776, BC055685, BE648035
      Consensus CDS
      CCDS52527.1
      UniProtKB/Swiss-Prot
      Q7TNU7
      Related
      ENSMUSP00000078160.7, ENSMUST00000079160.8
      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    RNA

    1. NR_157064.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156990, AC160526, AW048776, BC055685, BE648035

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      26068494..26088005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154069.1 → XP_036009962.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    2. XM_036154074.1 → XP_036009967.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    3. XM_006509130.5 → XP_006509193.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    4. XM_036154073.1 → XP_036009966.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    5. XM_030243591.2 → XP_030099451.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    6. XM_017312844.3 → XP_017168333.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    7. XM_036154072.1 → XP_036009965.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    8. XM_036154068.1 → XP_036009961.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    9. XM_006509124.5 → XP_006509187.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    10. XM_036154067.1 → XP_036009960.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    11. XM_030243592.2 → XP_030099452.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X7

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 204
      LETM1; LETM1-like protein

    12. XM_006509126.4 → XP_006509189.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    13. XM_006509125.4 → XP_006509188.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    14. XM_036154070.1 → XP_036009963.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 343
      LETM1; LETM1-like protein

    15. XM_030243590.2 → XP_030099450.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 343
      LETM1; LETM1-like protein

    16. XM_006509123.5 → XP_006509186.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    17. XM_036154071.1 → XP_036009964.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    18. XM_011242140.4 → XP_011240442.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

      Conserved Domains (2) summary
      TIGR04526
      Location:170 → 243
      predic_Ig_block; putative immunoglobulin-blocking virulence protein
      pfam07766
      Location:3 → 163
      LETM1; LETM1-like protein

    19. XM_030243594.2 → XP_030099454.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

      Conserved Domains (1) summary
      pfam07766
      Location:3 → 163
      LETM1; LETM1-like protein

    20. XM_006509128.5 → XP_006509191.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam07766
      Location:120 → 343
      LETM1; LETM1-like protein

    21. XM_006509127.4 → XP_006509190.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

      UniProtKB/Swiss-Prot
      Q7TNU7
      Conserved Domains (1) summary
      pfam07766
      Location:120 → 383
      LETM1; LETM1-like protein

    22. XM_030243593.1 → XP_030099453.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

      Conserved Domains (1) summary
      pfam07766
      Location:2 → 219
      LETM1; LETM1-like protein

    RNA

    1. XR_870217.4 RNA Sequence

    2. XR_003947290.2 RNA Sequence

    3. XR_003947291.2 RNA Sequence

    4. XR_004934835.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNU7.1 GenPept UniProtKB/Swiss-Prot:Q7TNU7

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