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    Ankib1 ankyrin repeat and IBR domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 368062, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Ankib1provided by RGD
    Official Full Name
    ankyrin repeat and IBR domain containing 1provided by RGD
    Primary source
    RGD:1597088
    See related
    EnsemblRapid:ENSRNOG00000005502 AllianceGenome:RGD:1597088
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ANKIB1 (ankyrin repeat and IBR domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 130.7), Brain (RPKM 99.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankib1 in Genome Data Viewer
    Location:
    4q13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (31288393..31412500)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (30333678..30457781)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (27473477..27597206)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeats and death domain containing 1 Neighboring gene uncharacterized LOC134486560 Neighboring gene KRIT1, ankyrin repeat containing Neighboring gene DND microRNA-mediated repression inhibitor 1, pseudogene 2 Neighboring gene transmembrane BAX inhibitor motif containing 7 Neighboring gene GATA zinc finger domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and IBR domain-containing protein 1
    NP_001128253.1
    XP_006236111.1
    XP_006236113.1
    XP_038963883.1
    XP_063142456.1
    XP_063142457.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134781.1 → NP_001128253.1  ankyrin repeat and IBR domain-containing protein 1

      See identical proteins and their annotated locations for NP_001128253.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JTL7
      Conserved Domains (5) summary
      cd00204
      Location:47 → 198
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50 → 176
      Ank_2; Ankyrin repeats (3 copies)
      pfam13639
      Location:334 → 380
      zf-RING_2; Ring finger domain
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      31288393..31412500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236049.5 → XP_006236111.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006236111.1

      UniProtKB/TrEMBL
      A0A0G2JTL7, A6K279, D4A731
      Related
      ENSRNOP00000007940.7, ENSRNOT00000007940.10
      Conserved Domains (4) summary
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]
      cd16774
      Location:333 → 389
      RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50 → 176
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_063286386.1 → XP_063142456.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6K279, D4A731

    3. XM_039107955.2 → XP_038963883.1  ankyrin repeat and IBR domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTL7, A6K279, D4A731
      Conserved Domains (4) summary
      sd00045
      Location:47 → 77
      ANK; ANK repeat [structural motif]
      cd16774
      Location:333 → 389
      RING-HC_RBR_ANKIB1; RING finger, HC subclass, found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins
      pfam01485
      Location:403 → 476
      IBR; IBR domain, a half RING-finger domain
      pfam12796
      Location:50 → 176
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_063286387.1 → XP_063142457.1  ankyrin repeat and IBR domain-containing protein 1 isoform X3

    5. XM_006236051.5 → XP_006236113.1  ankyrin repeat and IBR domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTL7
      Related
      ENSRNOP00000103631.1, ENSRNOT00000134030.1
      Conserved Domains (5) summary
      cd00204
      Location:12 → 145
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01485
      Location:350 → 423
      IBR; IBR domain, a half RING-finger domain
      pfam13639
      Location:281 → 327
      zf-RING_2; Ring finger domain
      pfam13857
      Location:80 → 133
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:26 → 90
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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