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    Nrsn2 neurensin 2 [ Mus musculus (house mouse) ]

    Gene ID: 228777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrsn2provided by MGI
    Official Full Name
    neurensin 2provided by MGI
    Primary source
    MGI:MGI:2684969
    See related
    Ensembl:ENSMUSG00000059361 AllianceGenome:MGI:2684969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm123; Neurensin-2
    Summary
    Predicted to be involved in nervous system development. Located in neuronal cell body and transport vesicle. Is expressed in brain. Orthologous to human NRSN2 (neurensin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 18.9), frontal lobe adult (RPKM 14.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nrsn2 in Genome Data Viewer
    Location:
    2 G3; 2 74.89 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152210675..152218560, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152368755..152376625, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11172 Neighboring gene tribbles pseudokinase 3 Neighboring gene STARR-seq mESC enhancer starr_06055 Neighboring gene predicted gene 14164 Neighboring gene ribosomal protein, large, P0 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06057 Neighboring gene VISTA enhancer mm271 Neighboring gene SRY (sex determining region Y)-box 12 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152231818-152232119 Neighboring gene zinc finger, CCHC domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants. Umschweif G, et al. Mol Psychiatry, 2021 Jul. PMID 33723417, Free PMC Article
    2. Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells. Nakanishi K, et al. Brain Res, 2006 Apr 7. PMID 16527258
    3. Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development. Tiklová K, et al. Nat Commun, 2019 Feb 4. PMID 30718509, Free PMC Article
    4. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants.
      Title: Activation of the p11/SMARCA3/Neurensin-2 pathway in parvalbumin interneurons mediates the response to chronic antidepressants.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Clone Names

    • MGC113772

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurensin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009948.2 → NP_001009948.1  neurensin-2 isoform 1

      See identical proteins and their annotated locations for NP_001009948.1

      Status: VALIDATED

      Source sequence(s)
      AL928568
      Consensus CDS
      CCDS16882.1
      UniProtKB/Swiss-Prot
      A2AS81, Q3USR0, Q5HZK2
      Related
      ENSMUSP00000078260.5, ENSMUST00000079278.5
      Conserved Domains (1) summary
      pfam14927
      Location:21 → 154
      Neurensin; Neurensin

    2. NM_001370749.1 → NP_001357678.1  neurensin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL928568
      Conserved Domains (1) summary
      pfam14927
      Location:2 → 93
      Neurensin

    3. NM_001370750.1 → NP_001357679.1  neurensin-2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL928568
      Conserved Domains (1) summary
      pfam14927
      Location:21 → 116
      Neurensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152210675..152218560 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499311.2 → XP_006499374.1  neurensin-2 isoform X1

      See identical proteins and their annotated locations for XP_006499374.1

      Conserved Domains (1) summary
      pfam14927
      Location:69 → 203
      Neurensin

    2. XM_006499312.5 → XP_006499375.1  neurensin-2 isoform X1

      See identical proteins and their annotated locations for XP_006499375.1

      Conserved Domains (1) summary
      pfam14927
      Location:69 → 203
      Neurensin

    3. XM_030250574.1 → XP_030106434.1  neurensin-2 isoform X2

      Conserved Domains (1) summary
      pfam14927
      Location:2 → 93
      Neurensin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZK2.1 GenPept UniProtKB/Swiss-Prot:Q5HZK2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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