Slc16a10 solute carrier family 16 (monocarboxylic acid transporters), member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a10provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 10provided by MGI
Primary source: MGI:MGI:1919722
See related: Ensembl:ENSMUSG00000019838 AllianceGenome:MGI:1919722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TAT1; Mct10; PRO0813; 9830169E08; 2610103N14Rik
Summary: Enables L-phenylalanine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in aromatic amino acid transport. Acts upstream of or within with a negative effect on thyroid hormone generation and thyroid-stimulating hormone secretion. Acts upstream of or within thyroid hormone transport. Located in basolateral plasma membrane. Is expressed in several structures, including brain; cochlea; humerus; liver; and metanephros. Orthologous to human SLC16A10 (solute carrier family 16 member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 16.2), genital fat pad adult (RPKM 15.9) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 21.48 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (39909528..40018262, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (40033532..40142270, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
Title: The Differential Effect of a Shortage of Thyroid Hormone Compared with Knockout of Thyroid Hormone Transporters Mct8 and Mct10 on Murine Macrophage Polarization.
The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice.
Title: The Thyroid Hormone Transporter MCT10 Is a Novel Regulator of Trabecular Bone Mass and Bone Turnover in Male Mice.
The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
Title: The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice.
We report hearing loss in mice with mutations in Slc16a2 and a related gene Slc16a10 (Mct10, Tat1). Deficiency of both transporters results in retarded development of the sensory epithelium similar to impairment caused by hypothyroidism, compounded with a progressive degeneration of cochlear hair cells and loss of endocochlear potential.
Title: Deafness and loss of cochlear hair cells in the absence of thyroid hormone transporters Slc16a2 (Mct8) and Slc16a10 (Mct10).
Mct10 participates in tissue-specific TH transport and also contributes to the generation of the unusual serum TH profile characteristic for Mct8 deficiency
Title: Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency.
Data indicate that the uniporter TAT1 is required to equilibrate the concentration of aromatic amino acids across specific membranes.
Title: T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control.
The results suggest that Mct10 functions as a thyroid hormone transporter in chondrocytes and can explain at least in part why Allan-Herndon-Dudley syndrome patients do not exhibit significant growth impairment.
Title: Monocarboxylate transporter 10 functions as a thyroid hormone transporter in chondrocytes.
expression of candidate thyroid hormone transporters Lat1, Mct8, Mct10, and Oatp1c1 in mouse cochlear development
Title: Developmental and cell-specific expression of thyroid hormone transporters in the mouse cochlea.
the aromatic amino acid diffusion pathway TAT1 can control neutral amino acid efflux via neighboring exchanger LAT2-4F2hc, by recycling its aromatic influx substrates
Title: Recycling of aromatic amino acids via TAT1 allows efflux of neutral amino acids via LAT2-4F2hc exchanger.
TAT1 is a basolateral epithelial transporter and can function as a net efflux pathway for aromatic amino acids. We propose that it may supply parallel exchangers with recycling uptake substrates that could drive the efflux of other amino acids.
Title: Basolateral aromatic amino acid transporter TAT1 (Slc16a10) functions as an efflux pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (5)
Transposon induced (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit53 (e-PCR), detects polymorphism
- UniSTS:126234

NoName (e-PCR)
- UniSTS:236332

Slc16a10 (e-PCR), detects polymorphism
- UniSTS:547398

RH126704 (e-PCR)
- UniSTS:167008

Slc16a10 (e-PCR), detects polymorphism
- UniSTS:545987

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-phenylalanine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-phenylalanine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-tryptophan transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tryptophan transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables L-tyrosine transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables L-tyrosine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables aromatic amino acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatic amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aromatic amino acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in aromatic amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in phenylalanine transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_negative_effect thyroid hormone generation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thyroid hormone transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within thyroid hormone transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within_negative_effect thyroid-stimulating hormone secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in tryptophan transport	IEA Inferred from Electronic Annotation more info
involved_in tyrosine transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocarboxylate transporter 10

Names: MCT 10; T-type amino acid transporter 1; aromatic amino acid transporter 1; solute carrier family 16 member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114332.1 → NP_001107804.1 monocarboxylate transporter 10 isoform 1

See identical proteins and their annotated locations for NP_001107804.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK151290, AK165240

Consensus CDS

CCDS48543.1

UniProtKB/Swiss-Prot

Q3TNJ1, Q3U9N9, Q3UAN9, Q8BWR7

Related

ENSMUSP00000090227.7, ENSMUST00000092566.8

Conserved Domains (2) summary

cd06174
Location:68 → 467

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00892
Location:53 → 484

2A0113; monocarboxylate transporter 1
NM_028247.4 → NP_082523.1 monocarboxylate transporter 10 isoform 2

See identical proteins and their annotated locations for NP_082523.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK165579

Consensus CDS

CCDS87990.1

UniProtKB/Swiss-Prot

Q3U9N9

Related

ENSMUSP00000150416.2, ENSMUST00000213488.2

Conserved Domains (1) summary

cd06174
Location:68 → 252

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

39909528..40018262 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512863.4 → XP_006512926.1 monocarboxylate transporter 10 isoform X1

UniProtKB/TrEMBL

Q7TPW2

Conserved Domains (1) summary

cl28910
Location:1 → 361

MFS; Major Facilitator Superfamily