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    Rpl7a ribosomal protein L7A [ Mus musculus (house mouse) ]

    Gene ID: 27176, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rpl7aprovided by MGI
    Official Full Name
    ribosomal protein L7Aprovided by MGI
    Primary source
    MGI:MGI:1353472
    See related
    Ensembl:ENSMUSG00000062647 AllianceGenome:MGI:1353472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Surf3
    Summary
    A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Located in cytoplasm; membrane; and ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in embryo; metanephros; neocortex; spleen; and thymus. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 336.0), CNS E11.5 (RPKM 322.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rpl7a in Genome Data Viewer
    Location:
    2 A3; 2 19.1 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26800697..26803330)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26910685..26913312)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene surfeit gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26758332-26758621 Neighboring gene mediator complex subunit 22 Neighboring gene predicted gene, 23969 Neighboring gene predicted gene, 22879 Neighboring gene predicted gene, 24134 Neighboring gene predicted gene, 57689 Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene serine/threonine kinase-like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury. Jiang Q, et al. Cell Physiol Biochem, 2018. PMID 29969783
    2. The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Williams TJ, et al. Mol Cell Biol, 1986 Dec. PMID 3025660, Free PMC Article
    3. One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes. Huxley C, et al. Mol Cell Biol, 1988 Sep. PMID 3221868, Free PMC Article
    4. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502
    5. The mouse surfeit locus contains a very tight cluster of four "housekeeping" genes that is conserved through evolution. Williams T, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 2453062, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103146

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL8
    Names
    60S ribosomal protein L7a
    surfeit 3
    surfeit locus protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013721.4 → NP_038749.1  large ribosomal subunit protein eL8

      See identical proteins and their annotated locations for NP_038749.1

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Consensus CDS
      CCDS15815.1
      UniProtKB/Swiss-Prot
      P12970, Q91YM3
      UniProtKB/TrEMBL
      Q58ET1, Q5EBG5, Q6P1A9
      Related
      ENSMUSP00000099962.5, ENSMUST00000102898.5
      Conserved Domains (1) summary
      PTZ00365
      Location:16 → 266
      PTZ00365; 60S ribosomal protein L7Ae-like; Provisional

    RNA

    1. NR_184739.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL773563
      Related
      ENSMUST00000143678.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      26800697..26803330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318923.2 → XP_017174412.1  large ribosomal subunit protein eL8 isoform X1

      Related
      ENSMUST00000137376.8
      Conserved Domains (1) summary
      PTZ00365
      Location:16 → 207
      PTZ00365; 60S ribosomal protein L7Ae-like; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P12970.2 GenPept UniProtKB/Swiss-Prot:P12970

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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