RGS13 regulator of G protein signaling 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS13provided by HGNC
Official Full Name: regulator of G protein signaling 13provided by HGNC
Primary source: HGNC:HGNC:9995
See related: Ensembl:ENSG00000127074 MIM:607190; AllianceGenome:HGNC:9995
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 52.7), appendix (RPKM 9.2) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q31.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (192636147..192660311)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (191983284..192007378)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (192605277..192629441)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrates for the first time that miR-139 and miR-452 negatively regulate RGS13 expression which is known to be involved in germinal centers regulation.
Title: MicroRNA and mRNA expression associated with ectopic germinal centers in thymus of myasthenia gravis.
p53 may modulate immune responses through suppression of RGS13 transcription in mast cells and B cells
Title: p53 negatively regulates RGS13 protein expression in immune cells.
RGS13 turnover was significantly reduced in cells stimulated with cAMP, which was reversed by expression of the PKA-specific inhibitory peptide PKI.
Title: Phosphorylation of RGS13 by the cyclic AMP-dependent protein kinase inhibits RGS13 degradation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
RGS13 overexpression inhibited CXCL12-evoked Ca(2+) mobilization, Akt phosphorylation and chemotaxis.
Title: RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
Functional characterization of the G protein regulator RGS13
Title: Functional characterization of the G protein regulator RGS13.
Down-Regulation of regulator of G-protein signalling 13 is associated with mantle cell lymphoma
Title: High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma.
RGS1 and RGS13 act together to regulate chemokine receptor signaling in human germinal center B lymphocytes and contribute significantly to the rapid desensitization of the signaling pathway.
Title: RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-76069 (e-PCR)
- UniSTS:77141

RGS13_2430 (e-PCR)
- UniSTS:280959

RH98634 (e-PCR)
- UniSTS:89813

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: regulator of G-protein signaling 13

Names: regulator of G-protein signalling 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002927.5 → NP_002918.1 regulator of G-protein signaling 13

See identical proteins and their annotated locations for NP_002918.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript.

Source sequence(s)

AL136454, AL596119

Consensus CDS

CCDS1376.1

UniProtKB/Swiss-Prot

O14921, Q6PGR2, Q8TD63, Q9BX45

Related

ENSP00000375853.2, ENST00000391995.7

Conserved Domains (1) summary

cd08716
Location:35 → 148

RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein
NM_144766.3 → NP_658912.1 regulator of G-protein signaling 13

See identical proteins and their annotated locations for NP_658912.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL136454, AL596119

Consensus CDS

CCDS1376.1

UniProtKB/Swiss-Prot

O14921, Q6PGR2, Q8TD63, Q9BX45

Related

ENSP00000442837.1, ENST00000543215.5

Conserved Domains (1) summary

cd08716
Location:35 → 148

RGS_RGS13; Regulator of G protein signaling (RGS) domain found in the RGS13 protein