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    VOPP1 VOPP1 WW domain binding protein [ Homo sapiens (human) ]

    Gene ID: 81552, updated on 27-Nov-2024

    Summary

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    Official Symbol
    VOPP1provided by HGNC
    Official Full Name
    VOPP1 WW domain binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:34518
    See related
    Ensembl:ENSG00000154978 MIM:611915; AllianceGenome:HGNC:34518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ECOP; GASP; WBP1L2
    Summary
    Enables enzyme binding activity. Located in cytoplasmic vesicle membrane; late endosome; and lysosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 19.1), appendix (RPKM 14.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See VOPP1 in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (55434964..55572502, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (55594635..55732784, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (55538301..55640195, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA exonuclease 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26012 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26014 Neighboring gene MPRA-validated peak6524 silencer Neighboring gene LanC like glutathione S-transferase 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:55470127-55471114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495178-55495682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55495683-55496185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55507999-55508825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55535735-55536236 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55540666-55541332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55545601-55546151 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55556042-55556542 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:55560767-55561966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55579955-55580476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55580477-55580998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55584685-55585190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55592347-55592848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26033 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:55606949-55607581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26035 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:55622524-55623470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18189 Neighboring gene Sharpr-MPRA regulatory region 1113 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26039 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26041 Neighboring gene VOPP1 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:55661073-55661572 Neighboring gene CDC42 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ECop (EGFR-coamplified and overexpressed protein), a novel protein, regulates NF-kappaB transcriptional activity and associated apoptotic response in an IkappaBalpha-dependent manner. Park S, et al. Oncogene, 2005 Apr 7. PMID 15735698
    2. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. Chung CH, et al. J Clin Oncol, 2006 Sep 1. PMID 16943533
    3. Molecular markers in patients with chronic wounds to guide surgical debridement. Brem H, et al. Mol Med, 2007 Jan-Feb. PMID 17515955, Free PMC Article
    4. The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation. Fang Z, et al. Cancer Biomark, 2020. PMID 32083568
    5. Molecular signature of cell cycle exit induced in human T lymphoblasts by IL-2 withdrawal. Chechlinska M, et al. BMC Genomics, 2009 Jun 8. PMID 19505301, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation.
      Title: The role of vesicular overexpressed in cancer pro-survival protein 1 in hepatocellular carcinoma proliferation.
    2. VOPP1 expression was negatively regulated by microRNA-218.
      Title: MicroRNA-218 alleviates sepsis inflammation by negatively regulating VOPP1 via JAK/STAT pathway.
    3. The findings emphasize the importance of the sequestration of WWOX by VOPP1 in addition to WWOX loss in breast tumors and define VOPP1 as a novel oncogene promoting breast carcinogenesis by inhibiting the anti-tumoral effect of WWOX.
      Title: VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX.
    4. miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression
      Title: miR-218 suppresses epithelial-to-mesenchymal transition by targeting Robo1 and Ecop in lung adenocarcinoma cells.
    5. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1.
      Title: Gene signatures of postoperative atrial fibrillation in atrial tissue after coronary artery bypass grafting surgery in patients receiving β-blockers.
    6. VOPP1 is overexpressed in gastric adenocarcinoma, which is involved in promoting cell proliferation and migration and thus might serve as a putative oncogene.
      Title: Epidermal growth factor receptor-coamplified and overexpressed protein (VOPP1) is a putative oncogene in gastric cancer.
    7. Upregulation of ECOP is associated with glioma.
      Title: MiR-218 sensitizes glioma cells to apoptosis and inhibits tumorigenicity by regulating ECOP-mediated suppression of NF-κB activity.
    8. overexpression in cancer participates in the control of the intracellular redox state; its loss leads to oxidative cellular injury leading to cell death by the intrinsic apoptotic pathway
      Title: Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    10. Results identify ECOP as a protein relevant to the biology of SCC.
      Title: Combined genomic and gene expression microarray profiling identifies ECOP as an upregulated gene in squamous cell carcinomas independent of DNA amplification.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20532, DKFZp564K0822

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in organelle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in organelle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WW domain binding protein VOPP1
    Names
    EGFR-coamplified and overexpressed protein
    Glioblastoma-amplified secreted protein
    VOPP1, WBP1/VOPP1 family member
    hypothetical protein DKFZp564K0822
    putative NF-kappa-B-activating protein 055N
    vesicular, overexpressed in cancer, prosurvival protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284282.2 → NP_001271211.1  WW domain binding protein VOPP1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK309288, HY076549
      Consensus CDS
      CCDS64656.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000393210.1, ENST00000418904.5
      Conserved Domains (1) summary
      cl28929
      Location:88 → 146
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    2. NM_001284283.2 → NP_001271212.1  WW domain binding protein VOPP1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK315882, DA814621, HY076549
      Consensus CDS
      CCDS64655.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000486983.1, ENST00000625836.2
      Conserved Domains (1) summary
      PRK13729
      Location:102 → 160
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    3. NM_001284284.1 → NP_001271213.1  WW domain binding protein VOPP1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' most structure and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC073347, AK092992, HY073578, HY076549
      Consensus CDS
      CCDS64654.1
      UniProtKB/Swiss-Prot
      Q96AW1
      Related
      ENSP00000415230.1, ENST00000433959.5
      Conserved Domains (1) summary
      pfam06679
      Location:81 → 124
      DUF1180; Protein of unknown function (DUF1180)

    4. NM_001321242.1 → NP_001308171.1  WW domain binding protein VOPP1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC073237, AC073347, DA991268, HY076549

    5. NM_001321243.2 → NP_001308172.1  WW domain binding protein VOPP1 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC073347, DB475432, HY057980, HY076549

    6. NM_001321244.2 → NP_001308173.1  WW domain binding protein VOPP1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC073347, AC099681, DA732543, DB496308, HY076549
      Consensus CDS
      CCDS83187.1
      UniProtKB/TrEMBL
      C9JVH1
      Related
      ENSP00000407356.1, ENST00000427700.1
      Conserved Domains (1) summary
      PRK13729
      Location:103 → 161
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    7. NM_001321246.2 → NP_001308175.1  WW domain binding protein VOPP1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC073347, DA257111, DB475432, HY076549
      Conserved Domains (1) summary
      PRK13729
      Location:79 → 137
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    8. NM_001321247.2 → NP_001308176.1  WW domain binding protein VOPP1 isoform 9 precursor

      Status: VALIDATED

      Source sequence(s)
      AC073347, BI597655, DB475432, HY076549

    9. NM_001321248.2 → NP_001308177.1  WW domain binding protein VOPP1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC073347, DA530391, HY076549
      Consensus CDS
      CCDS83186.1
      UniProtKB/TrEMBL
      C9J827, C9JIM1
      Related
      ENSP00000411447.1, ENST00000454227.5
      Conserved Domains (1) summary
      PRK13729
      Location:42 → 100
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional

    10. NM_001321249.2 → NP_001308178.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073347, HY032103, HY076549

    11. NM_001321250.2 → NP_001308179.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073347, AK090825, HY076549

    12. NM_001321251.1 → NP_001308180.1  WW domain binding protein VOPP1 isoform 11 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform 11. Variants 11, 12, and 13 all encode the same isoform (11).
      Source sequence(s)
      AC073237, AC073347, DA772419, HY076549

    13. NM_030796.5 → NP_110423.3  WW domain binding protein VOPP1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC073347, AK225755, DB496308, HY076549
      Consensus CDS
      CCDS47588.1
      UniProtKB/Swiss-Prot
      B0AZU1, B2RAT4, B3KS72, C9JWR3, Q6FIE3, Q8NBN8, Q96AW1, Q96RE5, Q9H0W4
      Related
      ENSP00000285279.5, ENST00000285279.10
      Conserved Domains (1) summary
      cl28929
      Location:105 → 163
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      55434964..55572502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515539.2 → XP_011513841.1  WW domain binding protein VOPP1 isoform X1

    2. XM_011515546.3 → XP_011513848.1  WW domain binding protein VOPP1 isoform X4

    3. XM_011515540.3 → XP_011513842.1  WW domain binding protein VOPP1 isoform X2

    4. XM_011515541.3 → XP_011513843.1  WW domain binding protein VOPP1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      55594635..55732784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359084.1 → XP_054215059.1  WW domain binding protein VOPP1 isoform X1

    2. XM_054359087.1 → XP_054215062.1  WW domain binding protein VOPP1 isoform X4

    3. XM_054359085.1 → XP_054215060.1  WW domain binding protein VOPP1 isoform X2

    4. XM_054359086.1 → XP_054215061.1  WW domain binding protein VOPP1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96AW1.1 GenPept UniProtKB/Swiss-Prot:Q96AW1

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