POSTN periostin [Homo sapiens (human)] - Gene

Summary

Official Symbol: POSTNprovided by HGNC
Official Full Name: periostinprovided by HGNC
Primary source: HGNC:HGNC:16953
See related: Ensembl:ENSG00000133110 MIM:608777; AllianceGenome:HGNC:16953
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PN; OSF2; OSF-2; PDLPOSTN
Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression: Broad expression in skin (RPKM 83.7), urinary bladder (RPKM 52.8) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q13.3

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (37562585..37598768, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (36781967..36818162, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (38136722..38172905, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrated single-cell and bulk RNA sequencing identifies POSTN as a potential biomarker and therapeutic target for rheumatoid arthritis.
Title: Integrated single-cell and bulk RNA sequencing identifies POSTN as a potential biomarker and therapeutic target for rheumatoid arthritis.
POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/beta-catenin and NF-kappaB signal pathway in intervertebral disc degeneration.
Title: POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/β-catenin and NF-κB signal pathway in intervertebral disc degeneration.
Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling.
Title: Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling.
POSTN Regulates Fibroblast Proliferation and Migration in Laryngotracheal Stenosis Through the TGF-beta/RHOA Pathway.
Title: POSTN Regulates Fibroblast Proliferation and Migration in Laryngotracheal Stenosis Through the TGF-β/RHOA Pathway.
Tumor-derived exosomal long noncoding RNA LINC01133, regulated by Periostin, contributes to pancreatic ductal adenocarcinoma epithelial-mesenchymal transition through the Wnt/beta-catenin pathway by silencing AXIN2.
Title: Tumor-derived exosomal long noncoding RNA LINC01133, regulated by Periostin, contributes to pancreatic ductal adenocarcinoma epithelial-mesenchymal transition through the Wnt/β-catenin pathway by silencing AXIN2.
Rescuing effects of periostin in advanced glycation end-products (AGEs) caused osteogenic and oxidative damage through AGE receptor mediation and DNA methylation of the CALCA promoter.
Title: Rescuing effects of periostin in advanced glycation end-products (AGEs) caused osteogenic and oxidative damage through AGE receptor mediation and DNA methylation of the CALCA promoter.
Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration.
Title: Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration.
Single-cell analysis identified POSTN[+] cells associated with the aggressive phenotype and risk of esophageal squamous cell carcinoma.
Title: Single-cell analysis identified POSTN(+) cells associated with the aggressive phenotype and risk of esophageal squamous cell carcinoma.
ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
Title: ALK upregulates POSTN and WNT signaling to drive neuroblastoma.
The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis.
Title: The gene expression of CALD1, CDH2, and POSTN in fibroblast are related to idiopathic pulmonary fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (386)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD. EBI GWAS Catalog EBI GWAS CatalogPubMed
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced downregulation of periostin, osteoblast specific factor (POSTN) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S1689 (e-PCR)
- UniSTS:9821

STS-H12747 (e-PCR)
- UniSTS:1681

UniSTS:234679 (e-PCR)
- UniSTS:234679

D13S1465 (e-PCR)
- UniSTS:16830

OSF-2 (e-PCR)
- UniSTS:480192

POSTN__5748 (e-PCR)
- UniSTS:463817

RH70782 (e-PCR)
- UniSTS:29924

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in bone regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vitamin K	IDA Inferred from Direct Assay more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	IEA Inferred from Electronic Annotation more info
involved_in neuron projection extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to muscle activity	IEA Inferred from Electronic Annotation more info
involved_in tissue development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: periostin

Names: osteoblast specific factor 2 (fasciclin I-like); periodontal ligament-specific periostin; periostin, osteoblast specific factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135934.2 → NP_001129406.1 periostin isoform 2 precursor

See identical proteins and their annotated locations for NP_001129406.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AI580215, BC106710, BG938993, DC403736

Consensus CDS

CCDS45034.1

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000369066.4, ENST00000379742.4

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001135935.2 → NP_001129407.1 periostin isoform 3 precursor

See identical proteins and their annotated locations for NP_001129407.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (3, also known as thy6) is shorter than isoform 1.

Source sequence(s)

AI580215, AY140646, BQ575951, DC403736

Consensus CDS

CCDS53864.1

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000437959.1, ENST00000541179.5

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001135936.2 → NP_001129408.1 periostin isoform 4 precursor

See identical proteins and their annotated locations for NP_001129408.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AI580215, AY918092, BP335818, BQ575951, BY795054, DC403736

UniProtKB/TrEMBL

C0IMJ3

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001286665.2 → NP_001273594.1 periostin isoform 5 precursor

See identical proteins and their annotated locations for NP_001273594.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (5, also known as thy2) is shorter than isoform 1.

Source sequence(s)

AI580215, AY140646, BQ575951, DC403736, EU262883

Consensus CDS

CCDS66531.1

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000369067.4, ENST00000379743.8

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001286666.2 → NP_001273595.1 periostin isoform 6 precursor

See identical proteins and their annotated locations for NP_001273595.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks three alternate in-frame exons, compared to variant 1. The encoded isoform (6, also known as thy4) is shorter than isoform 1.

Source sequence(s)

AI580215, AY140646, BQ575951, DC403736, EU262884

Consensus CDS

CCDS66530.1

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000437953.1, ENST00000541481.5

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001286667.2 → NP_001273596.1 periostin isoform 7 precursor

See identical proteins and their annotated locations for NP_001273596.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks four alternate in-frame exons, compared to variant 1. The encoded isoform (7, also known as thy8) is shorter than isoform 1.

Source sequence(s)

AI580215, AY140646, BQ575951, DC403736, EU262886

UniProtKB/TrEMBL

C0IMJ3

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain
NM_001330517.2 → NP_001317446.1 periostin isoform 8 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (8) is shorter than isoform 1.

Source sequence(s)

AI580215, BC106709, BQ575951, DC403736, JG969042

Consensus CDS

CCDS81764.1

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000369073.4, ENST00000379749.8
NM_001424172.1 → NP_001411101.1 periostin isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AL138679, AL646087
NM_001424173.1 → NP_001411102.1 periostin isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AL138679, AL646087
NM_001424174.1 → NP_001411103.1 periostin isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AL138679, AL646087
NM_006475.3 → NP_006466.2 periostin isoform 1 precursor

See identical proteins and their annotated locations for NP_006466.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI580215, BC106709, BQ575951, D13666, DC403736

Consensus CDS

CCDS9364.1

UniProtKB/Swiss-Prot

B1ALD8, B1ALD9, C0IMJ1, C0IMJ2, C0IMJ4, D2KRH7, F5H628, Q15063, Q15064, Q29XZ0, Q3KPJ5, Q5VSY5, Q8IZF9

UniProtKB/TrEMBL

C0IMJ3

Related

ENSP00000369071.4, ENST00000379747.9

Conserved Domains (1) summary

pfam02469
Location:245 → 367

Fasciclin; Fasciclin domain