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    Dip-C Dipeptidase C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47769, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dip-Cprovided by FlyBase
    Official Full Name
    Dipeptidase Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000455
    Locus tag
    Dmel_CG5663
    See related
    AllianceGenome:FB:FBgn0000455
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5663; dipC; Dmel\CG5663
    Summary
    Enables proline dipeptidase activity. Involved in proteolysis. Is expressed in several structures, including adult head; circulatory system primordium; embryonic/larval garland cell; embryonic/larval midgut; and head mesoderm. Human ortholog(s) of this gene implicated in prolidase deficiency. Orthologous to human PEPD (peptidase D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dip-C in Genome Data Viewer
    Location:
    87B9-87B9; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12411809..12413759, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8237531..8239481, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 649 Neighboring gene protein partner of snf Neighboring gene Sarcoglycan beta Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dipeptidase-C in Drosophila melanogaster: genetic, ontogenetic, and tissue-specific variation. Hiraizumi K, et al. Biochem Genet, 1992 Dec. PMID 1296574
    2. Comparative studies of allozyme loci in Drosophila simulans and Drosophila melanogaster. I. Three dipeptidase loci. Ohnishi S, et al. Biochem Genet, 1981 Feb. PMID 6784720
    3. Genetic, ontogenetic, and tissue-specific variation of dipeptidases in Drosophila melanogaster. Laurie-Ahlberg CC. Biochem Genet, 1982 Jun. PMID 6810870
    4. Genetic and environmental effects on the expression of peptidases and larval viability in Drosophila melanogaster. Hiraizumi K, et al. Genetics, 1992 Jul. PMID 1628808, Free PMC Article
    5. Chromosomal effects on peptidase activities in Drosophila melanogaster. Hiraizumi K, et al. Biochem Genet, 1993 Feb. PMID 8471022

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dipeptidase C
    Names
    CG5663-PA
    CG5663-PB
    Dip-C-PA
    Dip-C-PB
    NP_001287306.1
    NP_650192.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12411809..12413759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300377.1 → NP_001287306.1  dipeptidase C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RW4, Q9VG79
      Conserved Domains (3) summary
      PRK10879
      Location:57 → 483
      PRK10879; proline aminopeptidase P II; Provisional
      smart01011
      Location:12 → 158
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:195 → 468
      Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...

    2. NM_141935.4 → NP_650192.1  dipeptidase C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RW4, Q9VG79
      Related
      FBpp0082069
      Conserved Domains (3) summary
      PRK10879
      Location:57 → 483
      PRK10879; proline aminopeptidase P II; Provisional
      smart01011
      Location:12 → 158
      AMP_N; Aminopeptidase P, N-terminal domain
      cd01087
      Location:195 → 468
      Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VG79 Q9VG79

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