Got1 Glutamate oxaloacetate transaminase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Got1provided by FlyBase
Official Full Name: Glutamate oxaloacetate transaminase 1provided by FlyBase
Primary source: FLYBASE:FBgn0001124
Locus tag: Dmel_CG8430
See related: AllianceGenome:FB:FBgn0001124
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:GH07823; CG8430; Dmel\CG8430; FBgn 1124; Got-1; GOT-1; got1; GOT1; Got2
Summary: Enables L-aspartate:2-oxoglutarate aminotransferase activity. Involved in 2-oxoglutarate metabolic process; aspartate catabolic process; and glutamate biosynthetic process. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to several human genes including GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 52E7-52E10; 2-77 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16138352..16141928)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12025857..12029433)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 2-oxoglutarate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in aspartate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutamate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in malate-aspartate shuttle	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: glutamate oxaloacetate transaminase 1

Names: CG8430-PA; CG8430-PB; Got1-PA; Got1-PB; glutamate oxaloacetic transaminase

NP_611086.1

EC 2.6.1.-

EC 2.6.1.1

NP_725534.1

EC 2.6.1.-

EC 2.6.1.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16138352..16141928

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166148.2 → NP_725534.1 glutamate oxaloacetate transaminase 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725534.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAA5, Q8IHB4

Related

FBpp0086370

Conserved Domains (2) summary

PTZ00376
Location:21 → 423

PTZ00376; aspartate aminotransferase; Provisional

pfam00155
Location:49 → 418

Aminotran_1_2; Aminotransferase class I and II
NM_137242.3 → NP_611086.1 glutamate oxaloacetate transaminase 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611086.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K221, Q7YWB4

Related

FBpp0086371

Conserved Domains (2) summary

PTZ00376
Location:1 → 402

PTZ00376; aspartate aminotransferase; Provisional

pfam00155
Location:28 → 397

Aminotran_1_2; Aminotransferase class I and II