IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IGF2BP2provided by HGNC
Official Full Name: insulin like growth factor 2 mRNA binding protein 2provided by HGNC
Primary source: HGNC:HGNC:28867
See related: Ensembl:ENSG00000073792 MIM:608289; AllianceGenome:HGNC:28867
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IMP2; IMP-2; VICKZ2
Summary: This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]
Expression: Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q27.2

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (185643130..185825042, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (188458961..188640755, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (185360918..185542830, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
Title: METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
The m6A reader IGF2BP2 promotes ESCC progression by stabilizing HDGF mRNA.
Title: The m6A reader IGF2BP2 promotes ESCC progression by stabilizing HDGF mRNA.
CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.
Title: CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.
IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin-4 in an m[6]A-dependent manner.
Title: IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin-4 in an m(6)A-dependent manner.
The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.
Title: The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.
The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.
Title: The RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages.
Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
Title: Long noncoding RNA BMPR1B-AS1 stability regulated by IGF2BP2 affects the decidualization in endometriosis patients through the SMAD1/5/9 pathway.
The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.
Title: The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750.
m[6]A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.
Title: m(6)A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia.
The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA.
Title: The m6A reader IGF2BP2 promotes the progression of esophageal squamous cell carcinoma cells by increasing the stability of OCT4 mRNA.

Submit: New GeneRIF Correction See all GeneRIFs (186)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Type 2 diabetes mellitus MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder	Compare labs

EBI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of gestational diabetes mellitus in Korean women. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. EBI GWAS Catalog EBI GWAS CatalogPubMed
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three novel loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. EBI GWAS Catalog EBI GWAS CatalogPubMed
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. EBI GWAS Catalog EBI GWAS CatalogPubMed
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with insulin-like growth factor 2 mRNA binding protein 2 (IGF2BP2) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Rev	rev	Ectopic expression of IMP1 inhibits replication of HIV-1 in SupT1 cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-77627 (e-PCR)
- UniSTS:21024

RH70408 (e-PCR)
- UniSTS:40020

G32801 (e-PCR)
- UniSTS:117380

RH11318 (e-PCR)
- UniSTS:87687

RH12864 (e-PCR)
- UniSTS:67765

D3S4205 (e-PCR)
- UniSTS:20176

RH44937 (e-PCR)
- UniSTS:27605

A009S09 (e-PCR)
- UniSTS:1527

RH103717 (e-PCR)
- UniSTS:98042

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables N6-methyladenosine-containing RNA reader activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	HDA more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in CRD-mediated mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in CRD-mediated mRNA stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anatomical structure morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokine production	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 2 mRNA-binding protein 2

Names: IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; VICKZ family member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011602.1 RefSeqGene

Range

4998..186910

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007225.3 → NP_001007226.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform b

See identical proteins and their annotated locations for NP_001007226.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as p62) is shorter than isoform a.

Source sequence(s)

AC016961, AC108670

Consensus CDS

CCDS33903.1

UniProtKB/Swiss-Prot

Q9Y6M1

Related

ENSP00000320204.5, ENST00000346192.7

Conserved Domains (6) summary

cd12626
Location:2 → 78

RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd12629
Location:82 → 157

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22491
Location:195 → 268

KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22497
Location:383 → 459

KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22500
Location:466 → 543

KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cl00098
Location:276 → 352

KH-I; K homology (KH) RNA-binding domain, type I
NM_001291869.3 → NP_001278798.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform c

Status: REVIEWED

Source sequence(s)

AC016961, AC108670

Consensus CDS

CCDS77870.1

UniProtKB/TrEMBL

F8W930

Related

ENSP00000410242.2, ENST00000457616.6

Conserved Domains (4) summary

cd00105
Location:283 → 348

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:436 → 499

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cd12626
Location:2 → 78

RRM1_IGF2BP2; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cl17169
Location:82 → 163

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001291872.3 → NP_001278801.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform d

See identical proteins and their annotated locations for NP_001278801.1

Status: REVIEWED

Source sequence(s)

AC016961, AC108670, AI348863, BC021290, BX106919, EU408701

UniProtKB/Swiss-Prot

Q9Y6M1

Conserved Domains (5) summary

cd12629
Location:19 → 100

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22491
Location:138 → 211

KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22494
Location:219 → 295

KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22497
Location:369 → 445

KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22500
Location:452 → 529

KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
NM_001291873.3 → NP_001278802.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform e

See identical proteins and their annotated locations for NP_001278802.1

Status: REVIEWED

Source sequence(s)

AC016961, AC108670, AI348863, BC021290, BX106919, EU408702

Consensus CDS

CCDS77869.1

UniProtKB/Swiss-Prot

Q9Y6M1

Related

ENSP00000413787.3, ENST00000421047.3

Conserved Domains (5) summary

cd12629
Location:19 → 94

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22491
Location:132 → 205

KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22494
Location:213 → 289

KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22497
Location:363 → 439

KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22500
Location:446 → 523

KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins
NM_001291874.3 → NP_001278803.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform f

See identical proteins and their annotated locations for NP_001278803.1

Status: REVIEWED

Source sequence(s)

AC016961, AC108670, AI348863, AK296703, BC021290, BX106919, EU408703

UniProtKB/Swiss-Prot

Q9Y6M1

UniProtKB/TrEMBL

B4DKT5

Conserved Domains (4) summary

cd12629
Location:19 → 94

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22497
Location:320 → 396

KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22500
Location:403 → 480

KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cl00098
Location:213 → 289

KH-I; K homology (KH) RNA-binding domain, type I
NM_001291875.3 → NP_001278804.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform g

Status: REVIEWED

Source sequence(s)

AC016961, AC108670, AI348863, BC021290, BX106919, EU408704

UniProtKB/Swiss-Prot

Q9Y6M1

UniProtKB/TrEMBL

B3FTN5

Conserved Domains (3) summary

cd00105
Location:141 → 206

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:294 → 357

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cl17169
Location:1 → 21

RRM_SF; RNA recognition motif (RRM) superfamily
NM_006548.6 → NP_006539.3 insulin-like growth factor 2 mRNA-binding protein 2 isoform a

See identical proteins and their annotated locations for NP_006539.3

Status: REVIEWED

Source sequence(s)

AC016961, AI348863, AK290664, BC021290, BX106919, BY795845

Consensus CDS

CCDS3273.2

UniProtKB/Swiss-Prot

A0A4Z0, B3FTN2, B3FTN3, B3FTN4, Q9Y6M1

Related

ENSP00000371634.3, ENST00000382199.7

Conserved Domains (6) summary

cd12626
Location:2 → 78

RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd12629
Location:82 → 157

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22491
Location:195 → 268

KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22494
Location:276 → 352

KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22497
Location:426 → 502

KH-I_IGF2BP2_rpt3; third type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22500
Location:509 → 586

KH-I_IGF2BP2_rpt4; fourth type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

RNA

NR_138486.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an alternate segment in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC016961, AC108670

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

185643130..185825042 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047447325.1 → XP_047303281.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X16
XM_024453316.2 → XP_024309084.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X15

Conserved Domains (3) summary

cd00105
Location:141 → 206

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:294 → 357

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cl17169
Location:1 → 21

RRM_SF; RNA recognition motif (RRM) superfamily
XM_047447317.1 → XP_047303273.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X5
XM_017005557.3 → XP_016861046.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X1
XM_047447321.1 → XP_047303277.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X10
XM_047447316.1 → XP_047303272.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X4

Conserved Domains (5) summary

cd12626
Location:2 → 78

RRM1_IGF2BP2; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd12629
Location:82 → 157

RRM2_IGF2BP2; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

cd22491
Location:195 → 268

KH-I_IGF2BP2_rpt1; first type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cd22494
Location:276 → 352

KH-I_IGF2BP2_rpt2; second type I K homology (KH) RNA-binding domain found in insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and similar proteins

cl00098
Location:426 → 487

KH-I; K homology (KH) RNA-binding domain, type I
XM_047447319.1 → XP_047303275.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X8
XM_017005558.3 → XP_016861047.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X2
XM_017005559.3 → XP_016861048.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X3
XM_047447322.1 → XP_047303278.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X12
XM_047447323.1 → XP_047303279.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X13
XM_047447318.1 → XP_047303274.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X7
XM_017005560.3 → XP_016861049.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X6
XM_047447326.1 → XP_047303282.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X16
XM_047447320.1 → XP_047303276.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X9
XM_047447328.1 → XP_047303284.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X15
XM_047447329.1 → XP_047303285.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

UniProtKB/TrEMBL

B4DKT5
XM_047447330.1 → XP_047303286.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X21
XM_047447327.1 → XP_047303283.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X17
XM_006713477.5 → XP_006713540.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

See identical proteins and their annotated locations for XP_006713540.1

UniProtKB/TrEMBL

B4DKT5

Conserved Domains (3) summary

cd00105
Location:21 → 86

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:174 → 237

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

cl02570
Location:67 → 112

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
XM_047447324.1 → XP_047303280.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X14
XM_017005561.2 → XP_016861050.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X11
XM_017005564.2 → XP_016861053.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X18
XM_017005563.2 → XP_016861052.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X18

RNA

XR_007095624.1 RNA Sequence
XR_001739984.3 RNA Sequence
XR_007095628.1 RNA Sequence
XR_007095626.1 RNA Sequence
XR_007095625.1 RNA Sequence
XR_007095627.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

188458961..188640755 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054344981.1 → XP_054200956.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X16
XM_054344980.1 → XP_054200955.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X15
XM_054344970.1 → XP_054200945.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X5
XM_054344966.1 → XP_054200941.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X1
XM_054344975.1 → XP_054200950.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X10
XM_054344969.1 → XP_054200944.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X4
XM_054344973.1 → XP_054200948.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X8
XM_054344967.1 → XP_054200942.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X2
XM_054344968.1 → XP_054200943.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X3
XM_054344978.1 → XP_054200953.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X13
XM_054344971.1 → XP_054200946.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X6
XM_054344972.1 → XP_054200947.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X7
XM_054344977.1 → XP_054200952.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X12
XM_054344974.1 → XP_054200949.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X9
XM_054344986.1 → XP_054200961.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X15
XM_054344987.1 → XP_054200962.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X20

UniProtKB/TrEMBL

B4DKT5
XM_054344988.1 → XP_054200963.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X21
XM_054344982.1 → XP_054200957.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X17
XM_054344985.1 → XP_054200960.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X19

UniProtKB/TrEMBL

B4DKT5
XM_054344979.1 → XP_054200954.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X14
XM_054344976.1 → XP_054200951.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X11
XM_054344984.1 → XP_054200959.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X18
XM_054344983.1 → XP_054200958.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform X18