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    CYSLTR2 cysteinyl leukotriene receptor 2 [ Homo sapiens (human) ]

    Gene ID: 57105, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CYSLTR2provided by HGNC
    Official Full Name
    cysteinyl leukotriene receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:18274
    See related
    Ensembl:ENSG00000152207 MIM:605666; AllianceGenome:HGNC:18274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HG57; CYSLT2; GPCR21; HPN321; CYSLT2R; KPG_011; hGPCR21; PSEC0146
    Summary
    The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 7.8), heart (RPKM 2.8) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CYSLTR2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (48653929..48711226)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (47874204..47931486)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (49228065..49285362)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7736 Neighboring gene long intergenic non-protein coding RNA 1077 Neighboring gene uncharacterized LOC105370202 Neighboring gene Sharpr-MPRA regulatory region 13035 Neighboring gene long intergenic non-protein coding RNA 462 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:49323510-49324709 Neighboring gene proteasome activator subunit 2 pseudogene 2 Neighboring gene uncharacterized LOC107984559 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:49447591-49448313 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:49449130-49449638 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:49449639-49450147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7737

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Moore AR, et al. Nat Genet, 2016 Jun. PMID 27089179, Free PMC Article
    2. Genetic effect of CysLTR2 polymorphisms on its mRNA synthesis and stabilization. Shin JA, et al. BMC Med Genet, 2009 Oct 20. PMID 19840403, Free PMC Article
    3. Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. Brochu-Bourque A, et al. J Pharmacol Exp Ther, 2011 Feb. PMID 20966037
    4. Hyperleukotrieneuria in patients with allergic and inflammatory disease. Taniguchi M, et al. Allergol Int, 2008 Dec. PMID 18946233
    5. Cysteinyl leukotriene receptor 2 gene polymorphism -1220 A/C is not associated with atopic dermatitis or psoriasis vulgaris in Japanese patients. Kato T, et al. J Dermatol, 2011 May. PMID 21352274

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.
      Title: The IL-31/CysLT2R axis is associated with itching in patients with allergic rhinitis.
    2. DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
      Title: DNA Methylation and Gene Expression of the Cysteinyl Leukotriene Receptors as a Prognostic and Metastatic Factor for Colorectal Cancer Patients.
    3. Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.
      Title: Plasmalogen-Mediated Activation of GPCR21 Regulates Cytolytic Activity of NK Cells against the Target Cells.
    4. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch.
      Title: The CysLT(2)R receptor mediates leukotriene C(4)-driven acute and chronic itch.
    5. Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
      Title: Involvement of mutant and wild-type CYSLTR2 in the development and progression of uveal nevi and melanoma.
    6. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
      Title: Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling.
    7. Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
      Title: Mutations of GNAQ, GNA11, SF3B1, EIF1AX, PLCB4 and CYSLTR in Uveal Melanoma in Chinese Patients.
    8. findings indicate that CysLT2R was involved in inflammation and neuronal damage by inducing the activation of microglia M1 polarization and NF-kappaB pathway, inhibiting microglia M1 polarization and promoting microglia polarization toward M2 phenotype which may exerts neuroprotective effects.
      Title: Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1/M2 Polarization through NF-κB Pathway.
    9. Polymorphisms in the CYSLTR2 gene are associated with asthma, atopy markers and helminth infection in Brazilian individuals, which may lead to protection or risk for such conditions, however, more studies are needed to evaluate the functional of this variants here in described.
      Title: Variants in the CYSLTR2 are associated with asthma, atopy markers and helminths infections in the Brazilian population.
    10. CYSLTR2-mutant melanocytic blue neoplasms frequently exhibit a heavily pigmented exophytic tumor with a silhouette resembling "pigmented epithelioid melanocytoma" rather than usual cellular blue nevus.
      Title: CYSLTR2-mutant Cutaneous Melanocytic Neoplasms Frequently Simulate "Pigmented Epithelioid Melanocytoma," Expanding the Morphologic Spectrum of Blue Tumors: A Clinicopathologic Study of 7 Cases.
    Submit: New GeneRIF Correction See all GeneRIFs (48)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies ALLC polymorphisms correlated with FEV₁ change by corticosteroid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteinyl leukotriene receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    cysteinyl leukotriene receptor 2
    Names
    G-protein coupled receptor GPCR21
    G-protein coupled receptor HG57
    cysteinyl leukotriene CysLT2 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051649.1 RefSeqGene

      Range
      5219..62516
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308465.3 → NP_001295394.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295394.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (I) represents the longest transcript. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141523
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001308467.3 → NP_001295396.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295396.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (II) differs in the 5' UTR compared to variant 1. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141524
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001308468.3 → NP_001295397.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (III) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141525
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001308469.3 → NP_001295398.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141526
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_001308470.3 → NP_001295399.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295399.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141529
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_001308471.3 → NP_001295400.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295400.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141530
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Related
      ENSP00000282018.3, ENST00000282018.4
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. NM_001308476.3 → NP_001295405.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_001295405.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (V) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118, EF141527
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Related
      ENSP00000508181.1, ENST00000682523.1
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    8. NM_001387012.1 → NP_001373941.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    9. NM_001387013.1 → NP_001373942.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    10. NM_001387014.1 → NP_001373943.1  cysteinyl leukotriene receptor 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    11. NM_020377.5 → NP_065110.1  cysteinyl leukotriene receptor 2

      See identical proteins and their annotated locations for NP_065110.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (VI) differs in the 5' UTR compared to variant I. All 11 variants encode the same protein.
      Source sequence(s)
      AK291739, AL137118
      Consensus CDS
      CCDS9412.1
      UniProtKB/Swiss-Prot
      Q9HCQ2, Q9NS75
      UniProtKB/TrEMBL
      Q5KU17
      Related
      ENSP00000477930.1, ENST00000614739.4
      Conserved Domains (1) summary
      cd15157
      Location:39 → 316
      7tmA_CysLTR2; cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      48653929..48711226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      47874204..47931486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NS75.1 GenPept UniProtKB/Swiss-Prot:Q9NS75

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