Ncoa5 nuclear receptor coactivator 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ncoa5provided by MGI
Official Full Name: nuclear receptor coactivator 5provided by MGI
Primary source: MGI:MGI:2385165
See related: Ensembl:ENSMUSG00000039804 AllianceGenome:MGI:2385165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIA
Summary: Enables chromatin binding activity. Acts upstream of or within glucose homeostasis and negative regulation of insulin receptor signaling pathway. Predicted to be located in actin cytoskeleton. Predicted to be active in nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human NCOA5 (nuclear receptor coactivator 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 28.4), CNS E18 (RPKM 25.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.32 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164842273..164876794, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (165000353..165034871, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
Title: NCOA5 Haploinsufficiency in Myeloid-Lineage Cells Sufficiently Causes Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma.
NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
Title: NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21(WAF1/CIP1) overexpression, which is reversed by metformin.
NCOA5 functions as an LXR corepressor.A central role for NCOA5 in mediating crosstalk between pro-inflammatory and anti-inflammatory pathways that results in repression of macrophage cholesterol efflux.
Title: An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 5

Names: NCoA-5; coactivator independent of AF-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144892.1 → NP_659141.1 nuclear receptor coactivator 5

See identical proteins and their annotated locations for NP_659141.1

Status: VALIDATED

Source sequence(s)

BC017152

Consensus CDS

CCDS17068.1

UniProtKB/Swiss-Prot

A2A5L2, Q91W39

Related

ENSMUSP00000046388.9, ENSMUST00000040381.15

Conserved Domains (2) summary

COG0124
Location:186 → 256

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

PRK14971
Location:459 → 543

PRK14971; DNA polymerase III subunits gamma and tau; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164842273..164876794 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499369.5 → XP_006499432.2 nuclear receptor coactivator 5 isoform X1

UniProtKB/TrEMBL

B7ZC24

Related

ENSMUSP00000113166.2, ENSMUST00000122070.2

Conserved Domains (1) summary

COG0124
Location:186 → 256

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
XM_030250665.1 → XP_030106525.1 nuclear receptor coactivator 5 isoform X3

UniProtKB/TrEMBL

B7ZC23
XM_036161618.1 → XP_036017511.1 nuclear receptor coactivator 5 isoform X3

UniProtKB/TrEMBL

B7ZC23
XM_017317897.2 → XP_017173386.1 nuclear receptor coactivator 5 isoform X2

UniProtKB/TrEMBL

Q8BX12

Conserved Domains (1) summary

COG0124
Location:38 → 108

HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]