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    JMJD8 jumonji domain containing 8 [ Homo sapiens (human) ]

    Gene ID: 339123, updated on 27-Nov-2024

    Summary

    Official Symbol
    JMJD8provided by HGNC
    Official Full Name
    jumonji domain containing 8provided by HGNC
    Primary source
    HGNC:HGNC:14148
    See related
    Ensembl:ENSG00000161999 AllianceGenome:HGNC:14148
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP14397; C16orf20
    Summary
    Involved in several processes, including positive regulation of canonical NF-kappaB signal transduction; positive regulation of sprouting angiogenesis; and regulation of pyruvate kinase activity. Located in endoplasmic reticulum lumen and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 36.7), kidney (RPKM 34.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See JMJD8 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (681670..684334, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (685745..688409, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (731670..734334, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6939 Neighboring gene STUB1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6940 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:731189-731776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:731777-732364 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6941 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10212 Neighboring gene WD repeat domain 24 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:740279-740826 Neighboring gene F-box and leucine rich repeat protein 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10214 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:750057-750886

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    jmjC domain-containing protein 8
    Names
    jumonji domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005920.4NP_001005920.3  jmjC domain-containing protein 8 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      Z92544
      Consensus CDS
      CCDS45369.2
      UniProtKB/Swiss-Prot
      B2RNS7, D3DU58, Q4PKE3, Q4VBY1, Q6GMW5, Q71RB8, Q96S16
      Related
      ENSP00000477481.1, ENST00000609261.6
      Conserved Domains (1) summary
      cl21464
      Location:54248
      cupin_like; Conserved domain found in cupin and related proteins
    2. NM_001323918.3NP_001310847.2  jmjC domain-containing protein 8 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AI370749, BC137100, BX335015, HY073770, Z92544
      Conserved Domains (1) summary
      cl21464
      Location:54240
      cupin_like; Conserved domain found in cupin and related proteins
    3. NM_001323919.3NP_001310848.2  jmjC domain-containing protein 8 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AI370749, BC137100, BG481039, Z92544
      Consensus CDS
      CCDS92075.1
      UniProtKB/TrEMBL
      H3BVG3
      Related
      ENSP00000458106.1, ENST00000562111.1
    4. NM_001323920.3NP_001310849.2  jmjC domain-containing protein 8 isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AI370749, BI767435, Z92544
      Consensus CDS
      CCDS92074.1
      Related
      ENSP00000454358.1, ENST00000562824.5
      Conserved Domains (1) summary
      cl40423
      Location:34218
      cupin_RmlC-like; RmlC-like cupin superfamily
    5. NM_001323922.3NP_001310851.2  jmjC domain-containing protein 8 isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AI370749, BC137101, BG423721, CN371155, HY023676, HY073770, Z92544
      Conserved Domains (1) summary
      cl21464
      Location:34210
      cupin_like; Conserved domain found in cupin and related proteins

    RNA

    1. NR_136650.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF370420, AI370749, AL524336, HY073770, Z92544
      Related
      ENST00000568689.5
    2. NR_136651.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI370749, AL524922, CD674105, Z92544
    3. NR_136652.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AI370749, BC137100, BG284477, BG826580, HY073770, Z92544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      681670..684334 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      685745..688409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)