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    SPICE1 spindle and centriole associated protein 1 [ Homo sapiens (human) ]

    Gene ID: 152185, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SPICE1provided by HGNC
    Official Full Name
    spindle and centriole associated protein 1provided by HGNC
    Primary source
    HGNC:HGNC:25083
    See related
    Ensembl:ENSG00000163611 MIM:613447; AllianceGenome:HGNC:25083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPICE; CCDC52
    Summary
    Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in centriole; centrosome; and spindle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 3.6), endometrium (RPKM 3.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SPICE1 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (113442718..113515156, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (116163861..116236319, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (113161565..113234003, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SPICE1-CFAP44 readthrough (NMD candidate) Neighboring gene cilia and flagella associated protein 44 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:113085321-113085822 Neighboring gene RABGGTB pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 3247 Neighboring gene PHF5A pseudogene 2 Neighboring gene CFAP44 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20251 Neighboring gene microRNA 8076 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113176937-113177646 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:113177647-113178356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20252 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20255 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20257 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20258 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20260 Neighboring gene SID1 transmembrane family member 1 Neighboring gene SIDT1 antisense RNA 1 Neighboring gene microRNA 4446

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. SPICE--a previously uncharacterized protein required for centriole duplication and mitotic chromosome congression. Archinti M, et al. J Cell Sci, 2010 Sep 15. PMID 20736305
    2. CEP120 and SPICE1 cooperate with CPAP in centriole elongation. Comartin D, et al. Curr Biol, 2013 Jul 22. PMID 23810536
    3. A rapid computational approach identifies SPICE1 as an Aurora kinase substrate. Deretic J, et al. Mol Biol Cell, 2019 Feb 1. PMID 30485161, Free PMC Article
    4. Purification of CpG islands using a methylated DNA binding column. Cross SH, et al. Nat Genet, 1994 Mar. PMID 8012384
    5. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Fan X, et al. Stem Cell Res Ther, 2021 Feb 4. PMID 33541421, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CFAP44

    Readthrough SPICE1-CFAP44

    Readthrough gene: SPICE1-CFAP44, Included gene: CFAP44

    Homology

    Clone Names

    • FLJ26064, FLJ44949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase chromosome alignment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spindle and centriole-associated protein 1
    Names
    coiled-coil domain-containing protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331078.2 → NP_001318007.1  spindle and centriole-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    2. NM_001331079.2 → NP_001318008.2  spindle and centriole-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    3. NM_001387939.1 → NP_001374868.1  spindle and centriole-associated protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1-4 all encode the same protein.
      Source sequence(s)
      AC112128
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Conserved Domains (1) summary
      pfam15678
      Location:36 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    4. NM_144718.4 → NP_653319.1  spindle and centriole-associated protein 1

      See identical proteins and their annotated locations for NP_653319.1

      Status: VALIDATED

      Source sequence(s)
      AC112128, AY099107, BP278430, U79249
      Consensus CDS
      CCDS2973.1
      UniProtKB/Swiss-Prot
      D3DN72, Q8N0Z3, Q8WUX6
      Related
      ENSP00000295872.4, ENST00000295872.8
      Conserved Domains (1) summary
      pfam15678
      Location:36 → 434
      SPICE; Centriole duplication and mitotic chromosome congression

    RNA

    1. NR_170870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112128

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      113442718..113515156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      116163861..116236319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N0Z3.1 GenPept UniProtKB/Swiss-Prot:Q8N0Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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