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    Slc13a2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20500, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc13a2provided by MGI
    Official Full Name
    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1276558
    See related
    Ensembl:ENSMUSG00000001095 AllianceGenome:MGI:1276558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nadc1; Nadc-1; mNaDC-1
    Summary
    Enables sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in 4-cell stage embryo; nervous system; and sensory organ. Orthologous to human SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 77.1), large intestine adult (RPKM 68.5) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc13a2 in Genome Data Viewer
    Location:
    11 B5; 11 46.74 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78288102..78313107, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78397276..78422281, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene unc-119 lipid binding chaperone Neighboring gene STARR-positive B cell enhancer mm9_chr11:78173491-78173792 Neighboring gene predicted gene, 30367 Neighboring gene forkhead box N1 Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 46, member 1 Neighboring gene sterile alpha and HEAT/Armadillo motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene vitronectin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in alpha-ketoglutarate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alpha-ketoglutarate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to lithium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to lithium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lithium ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fumarate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fumarate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fumarate transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in succinate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in succinate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    solute carrier family 13 member 2
    Names
    Na(+)/dicarboxylate cotransporter 1
    renal sodium/dicarboxylate cotransporter
    sodium/dicarboxylate co-transporter

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022411.4NP_071856.1  solute carrier family 13 member 2

      See identical proteins and their annotated locations for NP_071856.1

      Status: VALIDATED

      Source sequence(s)
      AL591131
      Consensus CDS
      CCDS25103.1
      UniProtKB/Swiss-Prot
      Q9ES88
      Related
      ENSMUSP00000001122.6, ENSMUST00000001122.6
      Conserved Domains (2) summary
      TIGR00785
      Location:43553
      dass; anion transporter
      cl21473
      Location:6560
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78288102..78313107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532648.4XP_006532711.1  solute carrier family 13 member 2 isoform X3

      Conserved Domains (1) summary
      cl21473
      Location:28290
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    2. XM_006532645.4XP_006532708.1  solute carrier family 13 member 2 isoform X1

      Conserved Domains (1) summary
      cl21473
      Location:6380
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    3. XM_006532647.4XP_006532710.1  solute carrier family 13 member 2 isoform X2

      Conserved Domains (1) summary
      cl21473
      Location:6292
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
    4. XM_006532649.4XP_006532712.1  solute carrier family 13 member 2 isoform X4

      Conserved Domains (1) summary
      cl21473
      Location:6289
      ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

    RNA

    1. XR_003949367.1 RNA Sequence