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    Zmym2 zinc finger, MYM-type 2 [ Mus musculus (house mouse) ]

    Gene ID: 76007, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zmym2provided by MGI
    Official Full Name
    zinc finger, MYM-type 2provided by MGI
    Primary source
    MGI:MGI:1923257
    See related
    Ensembl:ENSMUSG00000021945 AllianceGenome:MGI:1923257
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FIM; MYM; RAMP; SCLL; Zfp198; Znf198; 5830413P05Rik
    Summary
    This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in CNS E11.5 (RPKM 12.5), CNS E14 (RPKM 11.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zmym2 in Genome Data Viewer
    Location:
    14 C3; 14 28.99 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57123986..57199815)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56886529..56962358)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22218 Neighboring gene STARR-seq mESC enhancer starr_36800 Neighboring gene STARR-seq mESC enhancer starr_36801 Neighboring gene cyclin I pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1896 Neighboring gene STARR-seq mESC enhancer starr_36803 Neighboring gene STARR-seq mESC enhancer starr_36804 Neighboring gene predicted gene, 36789 Neighboring gene RIKEN cDNA B020004C17 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of hematopoiesis by the fused in myeloproliferative disorders gene product. Inoue H, et al. Biochem Biophys Res Commun, 2004 Jan 2. PMID 14672707
    2. Proteomic analysis identifies ZMYM2 as endogenous binding partner of TBX18 protein in 293 and A549 cells. Lüdtke TH, et al. Biochem J, 2022 Jan 14. PMID 34935912
    3. Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease. Ren M, et al. Blood, 2011 Jun 23. PMID 21527531, Free PMC Article
    4. ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development. Graham-Paquin AL, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37395395, Free PMC Article
    5. Identification of novel Smad binding proteins. Warner DR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651998

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development.
      Title: ZMYM2 is essential for methylation of germline genes and active transposons in embryonic development.
    2. The study demonstrates frequent, constitutive activation of Notch1 and its downstream target genes in T-cell lymphomas that arose in a murine model of Zmym2-Fgfr1 stem cell leukemia-lymphoma syndrome.
      Title: Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC51607

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 2
    Names
    zinc finger protein 198

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360643.1 → NP_001347572.1  zinc finger MYM-type protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC154303, AK135499, AK137720, AV142652, BE993957, BU055093, CA536924, CV561457
      Consensus CDS
      CCDS49506.1
      UniProtKB/Swiss-Prot
      B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1197 → 1359
      DUF3504; Domain of unknown function (DUF3504)

    2. NM_029498.4 → NP_083774.2  zinc finger MYM-type protein 2 isoform 1

      See identical proteins and their annotated locations for NP_083774.2

      Status: REVIEWED

      Source sequence(s)
      AC154303, AK135499, AK137720, AV142652, BE993957, CA536924, CJ110016, CV561457
      Consensus CDS
      CCDS49506.1
      UniProtKB/Swiss-Prot
      B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
      Related
      ENSMUSP00000022511.9, ENSMUST00000022511.10
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1197 → 1359
      DUF3504; Domain of unknown function (DUF3504)

    3. NM_177627.3 → NP_808295.2  zinc finger MYM-type protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC154303, AK135499, CJ110016
      Consensus CDS
      CCDS88674.1
      UniProtKB/TrEMBL
      A0A286YCD5, Q80V89
      Related
      ENSMUSP00000152925.2, ENSMUST00000223669.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      57123986..57199815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245220.3 → XP_011243522.1  zinc finger MYM-type protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243522.1

      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1223 → 1385
      DUF3504; Domain of unknown function (DUF3504)

    2. XM_011245221.3 → XP_011243523.1  zinc finger MYM-type protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243523.1

      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1223 → 1385
      DUF3504; Domain of unknown function (DUF3504)

    3. XM_011245219.3 → XP_011243521.1  zinc finger MYM-type protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243521.1

      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1223 → 1385
      DUF3504; Domain of unknown function (DUF3504)

    4. XM_030248091.1 → XP_030103951.1  zinc finger MYM-type protein 2 isoform X2

      UniProtKB/Swiss-Prot
      B2RUS2, Q3UUZ8, Q3UXK7, Q80XP0, Q9CU65
      Conserved Domains (2) summary
      pfam06467
      Location:461 → 501
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
      pfam12012
      Location:1197 → 1359
      DUF3504; Domain of unknown function (DUF3504)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CU65.3 GenPept UniProtKB/Swiss-Prot:Q9CU65

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