Pcbp2 poly(rC) binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcbp2provided by MGI
Official Full Name: poly(rC) binding protein 2provided by MGI
Primary source: MGI:MGI:108202
See related: Ensembl:ENSMUSG00000056851 AllianceGenome:MGI:108202
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpx; alphaCP-2
Summary: Enables C-rich single-stranded DNA binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 95.3), limb E14.5 (RPKM 65.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F3; 15 57.61 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102378974..102408503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102470450..102500068)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
Title: Poly C Binding Protein 2 dependent nuclear retention of the utrophin-A mRNA in C2C12 cells.
RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
Title: RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis.
PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
Title: PCBP2 post-transcriptionally regulates sortilin expression by binding to a C-rich element in its 3' UTR.
Embryos lacking the KH domain poly(C) binding protein, Pcbp2, are selectively deficient in the definitive erythroid lineage. Compared to wild-type controls, transcript splicing analysis of the Pcbp2(-/-) embryonic liver reveals accentuated exclusion of an exon (exon 6) that encodes a highly conserved transcriptional control segment of the hematopoietic master regulator, Runx1.
Title: Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
These findings suggest that Hr mRNA expression is regulated at the post-transcriptional level via IRES-mediated translation control through interaction with PCPB2, but not in MUHH.
Title: Poly(rC) binding protein 2 acts as a negative regulator of IRES-mediated translation of Hr mRNA.
Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.
Title: Poly(rC)-Binding Protein 2 Regulates Hippo Signaling To Control Growth in Breast Epithelial Cells.
data suggest that PCBP2 regulates p73 expression via mRNA stability and p73-dependent biological function in ROS production and cellular senescence.
Title: RNA-binding Protein PCBP2 Regulates p73 Expression and p73-dependent Antioxidant Defense.
PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes.
Title: Meis1 promotes poly (rC)-binding protein 2 expression and inhibits angiotensin II-induced cardiomyocyte hypertrophy.
These data reveal that Pcbp1 and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.
Title: The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.
Title: The RNA-binding protein PCBP2 inhibits Ang II-induced hypertrophy of cardiomyocytes though promoting GPR56 mRNA degeneration.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pcbp2 (e-PCR), detects polymorphism
- UniSTS:144136

AW412548 (e-PCR)
- UniSTS:180842

stSG622577 (e-PCR)
- UniSTS:454819

AA924752 (e-PCR)
- UniSTS:261821

UniSTS:479190 (e-PCR)
- UniSTS:479190

Pcbp2 (e-PCR), detects polymorphism
- UniSTS:479190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables C-rich single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables iron chaperone activity	ISO Inferred from Sequence Orthology more info	PubMed
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-enhancer loop anchoring activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in IRES-dependent viral translational initiation	ISO Inferred from Sequence Orthology more info
involved_in chromatin looping	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cGAS/STING signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in viral RNA genome replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: poly(rC)-binding protein 2

Names: CBP; CTBP; alpha-CP2; heterogeneous nuclear ribonucleoprotein X; hnRNP X; putative heterogeneous nuclear ribonucleoprotein X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001103165.2 → NP_001096635.1 poly(rC)-binding protein 2 isoform 1

See identical proteins and their annotated locations for NP_001096635.1

Status: VALIDATED

Source sequence(s)

AC137156

Consensus CDS

CCDS49741.1

UniProtKB/Swiss-Prot

Q61383, Q61990, Q62042

Related

ENSMUSP00000076294.6, ENSMUST00000077037.13

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
NM_001103166.2 → NP_001096636.1 poly(rC)-binding protein 2 isoform 3

See identical proteins and their annotated locations for NP_001096636.1

Status: VALIDATED

Source sequence(s)

AC137156

Consensus CDS

CCDS49742.1

UniProtKB/Swiss-Prot

Q61990

UniProtKB/TrEMBL

Q3TT81

Related

ENSMUSP00000155430.2, ENSMUST00000229618.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:250 → 325

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
NM_001174073.2 → NP_001167544.1 poly(rC)-binding protein 2 isoform 4

See identical proteins and their annotated locations for NP_001167544.1

Status: VALIDATED

Source sequence(s)

AC137156

Consensus CDS

CCDS88856.1

UniProtKB/TrEMBL

Q3TT81

Related

ENSMUSP00000104466.5, ENSMUST00000108838.5

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:241 → 316

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
NM_001374771.1 → NP_001361700.1 poly(rC)-binding protein 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC137156

Consensus CDS

CCDS88857.1

UniProtKB/TrEMBL

B2M1R7

Related

ENSMUSP00000155789.2, ENSMUST00000230114.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:280 → 355

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
NM_001411538.1 → NP_001398467.1 poly(rC)-binding protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411539.1 → NP_001398468.1 poly(rC)-binding protein 2 isoform 1

Status: VALIDATED

Source sequence(s)

AC137156

UniProtKB/Swiss-Prot

Q61383, Q61990, Q62042
NM_001411540.1 → NP_001398469.1 poly(rC)-binding protein 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411541.1 → NP_001398470.1 poly(rC)-binding protein 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411542.1 → NP_001398471.1 poly(rC)-binding protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411543.1 → NP_001398472.1 poly(rC)-binding protein 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411544.1 → NP_001398473.1 poly(rC)-binding protein 2 isoform 7

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411545.1 → NP_001398474.1 poly(rC)-binding protein 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411546.1 → NP_001398475.1 poly(rC)-binding protein 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411547.1 → NP_001398476.1 poly(rC)-binding protein 2 isoform 8

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411548.1 → NP_001398477.1 poly(rC)-binding protein 2 isoform 9

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411549.1 → NP_001398478.1 poly(rC)-binding protein 2 isoform 10

Status: VALIDATED

Source sequence(s)

AC137156

UniProtKB/TrEMBL

B2M1R7
NM_001411550.1 → NP_001398479.1 poly(rC)-binding protein 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411551.1 → NP_001398480.1 poly(rC)-binding protein 2 isoform 11

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411552.1 → NP_001398481.1 poly(rC)-binding protein 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411553.1 → NP_001398482.1 poly(rC)-binding protein 2 isoform 12

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411554.1 → NP_001398483.1 poly(rC)-binding protein 2 isoform 13

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411555.1 → NP_001398484.1 poly(rC)-binding protein 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411556.1 → NP_001398485.1 poly(rC)-binding protein 2 isoform 15

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411557.1 → NP_001398486.1 poly(rC)-binding protein 2 isoform 13

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411558.1 → NP_001398487.1 poly(rC)-binding protein 2 isoform 16

Status: VALIDATED

Source sequence(s)

AC137156
NM_001411559.1 → NP_001398488.1 poly(rC)-binding protein 2 isoform 14

Status: VALIDATED

Source sequence(s)

AC137156
NM_011042.3 → NP_035172.2 poly(rC)-binding protein 2 isoform 2

See identical proteins and their annotated locations for NP_035172.2

Status: VALIDATED

Source sequence(s)

AC137156

Consensus CDS

CCDS27884.1

UniProtKB/Swiss-Prot

Q61990

UniProtKB/TrEMBL

Q3TT81

Related

ENSMUSP00000155038.2, ENSMUST00000229854.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:268 → 343

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102378974..102408503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248387.1 → XP_030104247.1 poly(rC)-binding protein 2 isoform X7

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:274 → 336

KH_1; KH domain
XM_006520582.4 → XP_006520645.1 poly(rC)-binding protein 2 isoform X16

See identical proteins and their annotated locations for XP_006520645.1

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:285 → 360

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_017316497.2 → XP_017171986.1 poly(rC)-binding protein 2 isoform X17

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:284 → 359

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_006520583.4 → XP_006520646.1 poly(rC)-binding protein 2 isoform X20

See identical proteins and their annotated locations for XP_006520646.1

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:272 → 347

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_017316499.2 → XP_017171988.1 poly(rC)-binding protein 2 isoform X21

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:271 → 346

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_006520584.4 → XP_006520647.1 poly(rC)-binding protein 2 isoform X24

See identical proteins and their annotated locations for XP_006520647.1

UniProtKB/TrEMBL

A0A2R8VHP9

Related

ENSMUSP00000155292.2, ENSMUST00000229802.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:254 → 329

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_030248401.1 → XP_030104261.1 poly(rC)-binding protein 2 isoform X25

Related

ENSMUSP00000155654.2, ENSMUST00000229184.2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:253 → 328

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_006520585.4 → XP_006520648.1 poly(rC)-binding protein 2 isoform X28

See identical proteins and their annotated locations for XP_006520648.1

UniProtKB/TrEMBL

Q3TT81

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:241 → 316

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_017316501.2 → XP_017171990.1 poly(rC)-binding protein 2 isoform X29

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:240 → 315

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_011245495.3 → XP_011243797.1 poly(rC)-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243797.1

UniProtKB/TrEMBL

A0AAQ4VMQ7

Related

ENSMUSP00000159956.1, ENSMUST00000249860.1

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:285 → 360

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_011245497.3 → XP_011243799.1 poly(rC)-binding protein 2 isoform X2

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:284 → 359

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_011245501.3 → XP_011243803.1 poly(rC)-binding protein 2 isoform X5

See identical proteins and their annotated locations for XP_011243803.1

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:272 → 347

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_011245502.3 → XP_011243804.1 poly(rC)-binding protein 2 isoform X6

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:271 → 346

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_011245503.3 → XP_011243805.1 poly(rC)-binding protein 2 isoform X9

See identical proteins and their annotated locations for XP_011243805.1

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:254 → 329

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_030248391.1 → XP_030104251.1 poly(rC)-binding protein 2 isoform X10

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:259 → 321

KH_1; KH domain
XM_030248392.1 → XP_030104252.1 poly(rC)-binding protein 2 isoform X13

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:241 → 316

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_030248389.1 → XP_030104249.1 poly(rC)-binding protein 2 isoform X8

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:273 → 335

KH_1; KH domain
XM_030248394.1 → XP_030104254.1 poly(rC)-binding protein 2 isoform X15

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:242 → 304

KH_1; KH domain
XM_011245496.2 → XP_011243798.1 poly(rC)-binding protein 2 isoform X1

See identical proteins and their annotated locations for XP_011243798.1

UniProtKB/TrEMBL

A0AAQ4VMQ7

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:285 → 360

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins
XM_030248390.1 → XP_030104250.1 poly(rC)-binding protein 2 isoform X8

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:273 → 335

KH_1; KH domain
XM_030248393.1 → XP_030104253.1 poly(rC)-binding protein 2 isoform X14

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:243 → 305

KH_1; KH domain
XM_011245509.2 → XP_011243811.1 poly(rC)-binding protein 2 isoform X15

Conserved Domains (2) summary

cd02396
Location:99 → 163

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

pfam00013
Location:242 → 304

KH_1; KH domain
XM_030248396.1 → XP_030104256.1 poly(rC)-binding protein 2 isoform X18

UniProtKB/Swiss-Prot

Q61383, Q61990, Q62042

Conserved Domains (3) summary

cd22515
Location:13 → 82

KH-I_PCBP1_2_rpt1; first type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22518
Location:92 → 169

KH-I_PCBP1_2_rpt2; second type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins

cd22521
Location:281 → 356

KH-I_PCBP1_2_rpt3; third type I K homology (KH) RNA-binding domain found in poly(rC)-binding protein 1 (PCBP1) and similar proteins