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    Tssk5 testis-specific serine kinase 5 [ Mus musculus (house mouse) ]

    Gene ID: 73542, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tssk5provided by MGI
    Official Full Name
    testis-specific serine kinase 5provided by MGI
    Primary source
    MGI:MGI:1920792
    See related
    Ensembl:ENSMUSG00000060794 AllianceGenome:MGI:1920792
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSK-5; 1700091F14Rik
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Is expressed in metanephros; submandibular gland; and testis. Orthologous to human TSSK5P (testis specific serine kinase 5, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 21.6) See more
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    Genomic context

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    See Tssk5 in Genome Data Viewer
    Location:
    15 D3; 15 35.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76256158..76259391, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76371958..76375191, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39052 Neighboring gene WD repeat domain 97 Neighboring gene STARR-positive B cell enhancer ABC_E11592 Neighboring gene STARR-positive B cell enhancer ABC_E1912 Neighboring gene HGH1 homolog Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis scleraxis bHLH transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 5
    Names
    testis-specific kinase 5
    NP_898922.2
    XP_011244046.1
    XP_011244047.1
    XP_011244048.1
    XP_011244049.1
    XP_011244050.1
    XP_017172248.1
    XP_030104654.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183099.2 → NP_898922.2  testis-specific serine/threonine-protein kinase 5

      See identical proteins and their annotated locations for NP_898922.2

      Status: VALIDATED

      Source sequence(s)
      AK007032, BC114543
      Consensus CDS
      CCDS37122.1
      UniProtKB/Swiss-Prot
      Q1WWK7, Q8C1R0
      Related
      ENSMUSP00000071120.7, ENSMUST00000071119.8
      Conserved Domains (2) summary
      smart00220
      Location:31 → 302
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:26 → 301
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76256158..76259391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248794.1 → XP_030104654.1  testis-specific serine/threonine-protein kinase 5 isoform X4

      Conserved Domains (1) summary
      cl21453
      Location:2 → 236
      PKc_like; Protein Kinases, catalytic domain

    2. XM_017316759.2 → XP_017172248.1  testis-specific serine/threonine-protein kinase 5 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:26 → 254
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011245744.3 → XP_011244046.1  testis-specific serine/threonine-protein kinase 5 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:26 → 301
      PKc_like; Protein Kinases, catalytic domain

    4. XM_011245745.3 → XP_011244047.1  testis-specific serine/threonine-protein kinase 5 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:26 → 295
      PKc_like; Protein Kinases, catalytic domain

    5. XM_011245748.3 → XP_011244050.1  testis-specific serine/threonine-protein kinase 5 isoform X5

      See identical proteins and their annotated locations for XP_011244050.1

      Conserved Domains (1) summary
      cl21453
      Location:26 → 235
      PKc_like; Protein Kinases, catalytic domain

    6. XM_011245746.3 → XP_011244048.1  testis-specific serine/threonine-protein kinase 5 isoform X5

      See identical proteins and their annotated locations for XP_011244048.1

      Conserved Domains (1) summary
      cl21453
      Location:26 → 235
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011245747.3 → XP_011244049.1  testis-specific serine/threonine-protein kinase 5 isoform X6

      Conserved Domains (1) summary
      cl21453
      Location:26 → 237
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_875314.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C1R0.2 GenPept UniProtKB/Swiss-Prot:Q8C1R0

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