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    Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) [ Mus musculus (house mouse) ]

    Gene ID: 240057, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Syngap1provided by MGI
    Official Full Name
    synaptic Ras GTPase activating protein 1 homolog (rat)provided by MGI
    Primary source
    MGI:MGI:3039785
    See related
    Ensembl:ENSMUSG00000067629 AllianceGenome:MGI:3039785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1963; Syngap
    Summary
    This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
    Expression
    Broad expression in frontal lobe adult (RPKM 23.1), cortex adult (RPKM 20.3) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Syngap1 in Genome Data Viewer
    Location:
    17 A3.3; 17 13.6 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27160186..27191408)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26941212..26972434)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene microRNA 6968 Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene gametogenetin binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene BCL2-antagonist/killer 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability. Fenton TA, et al. Transl Psychiatry, 2024 Oct 2. PMID 39358332, Free PMC Article
    2. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly. Aceti M, et al. Biol Psychiatry, 2015 May 1. PMID 25444158, Free PMC Article
    3. Decrease of SYNGAP1 in GABAergic cells impairs inhibitory synapse connectivity, synaptic inhibition and cognitive function. Berryer MH, et al. Nat Commun, 2016 Nov 9. PMID 27827368, Free PMC Article
    4. SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity. Clement JP, et al. J Neurosci, 2013 Jun 19. PMID 23785156, Free PMC Article
    5. Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout. Muhia M, et al. Learn Mem, 2012 Jun 14. PMID 22700469

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.
      Title: Hyperexcitability and translational phenotypes in a preclinical mouse model of SYNGAP1-related intellectual disability.
    2. SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
      Title: SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity.
    3. Mouse models of SYNGAP1-related intellectual disability.
      Title: Mouse models of SYNGAP1-related intellectual disability.
    4. Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.
      Title: Upregulation of SYNGAP1 expression in mice and human neurons by redirecting alternative splicing.
    5. Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.
      Title: Syngap1 Disruption Induced by Recombination between Inverted loxP Sites Is Associated with Hippocampal Interneuron Dysfunction.
    6. Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection.
      Title: Endogenous Syngap1 alpha splice forms promote cognitive function and seizure protection.
    7. Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
      Title: Learning and reaction times in mouse touchscreen tests are differentially impacted by mutations in genes encoding postsynaptic interacting proteins SYNGAP1, NLGN3, DLGAP1, DLGAP2 and SHANK2.
    8. Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening.
      Title: Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening.
    9. SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.
      Title: SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity.
    10. pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors.
      Title: pSynGAP1 disturbance-mediated hippocampal oscillation network impairment might contribute to long-term neurobehavioral abnormities in sepsis survivors.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic specialization structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maintenance of postsynaptic specialization structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of axonogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras/Rap GTPase-activating protein SynGAP
    Names
    neuronal RasGAP
    ras GTPase-activating protein SynGAP
    synaptic Ras GTPase-activating protein 1
    synaptic Ras-GAP 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281491.2 → NP_001268420.1  ras/Rap GTPase-activating protein SynGAP isoform 1

      See identical proteins and their annotated locations for NP_001268420.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC144621
      Consensus CDS
      CCDS59625.1
      UniProtKB/Swiss-Prot
      F6SEU4
      UniProtKB/TrEMBL
      A0A2S1B6B8
      Related
      ENSMUSP00000141686.2, ENSMUST00000194598.6
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1307
      DUF3498; Domain of unknown function (DUF3498)

    2. NM_001371033.1 → NP_001357962.1  ras/Rap GTPase-activating protein SynGAP isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC144621
      UniProtKB/TrEMBL
      A0A2S1B6B8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1305
      DUF3498; Domain of unknown function (DUF3498)

    3. NM_001371034.1 → NP_001357963.1  ras/Rap GTPase-activating protein SynGAP isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC144621
      UniProtKB/TrEMBL
      A0A0J9YVH8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1245
      DUF3498; Domain of unknown function (DUF3498)

    4. NM_001394027.1 → NP_001380956.1  ras/Rap GTPase-activating protein SynGAP isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC144621
      UniProtKB/TrEMBL
      A0A2S1B6F9
      Related
      ENSMUSP00000080038.5, ENSMUST00000081285.9
      Conserved Domains (4) summary
      cd04013
      Location:166 → 328
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:319 → 642
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:36 → 227
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      TIGR02169
      Location:1084 → 1207
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27160186..27191408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524237.2 → XP_006524300.1  ras/Rap GTPase-activating protein SynGAP isoform X5

      UniProtKB/TrEMBL
      A0A0J9YUM2
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1278
      DUF3498; Domain of unknown function (DUF3498)

    2. XM_006524245.3 → XP_006524308.1  ras/Rap GTPase-activating protein SynGAP isoform X14

      See identical proteins and their annotated locations for XP_006524308.1

      UniProtKB/TrEMBL
      A0A0J9YVH8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1261
      DUF3498; Domain of unknown function (DUF3498)

    3. XM_006524240.2 → XP_006524303.1  ras/Rap GTPase-activating protein SynGAP isoform X7

      UniProtKB/TrEMBL
      A0A2S1B6B8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1308
      DUF3498; Domain of unknown function (DUF3498)

    4. XM_030249787.1 → XP_030105647.1  ras/Rap GTPase-activating protein SynGAP isoform X15

      UniProtKB/TrEMBL
      A0A0J9YVH8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1259
      DUF3498; Domain of unknown function (DUF3498)

    5. XM_030249784.1 → XP_030105644.1  ras/Rap GTPase-activating protein SynGAP isoform X9

      UniProtKB/TrEMBL
      A0A2S1B6B8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1291
      DUF3498; Domain of unknown function (DUF3498)

    6. XM_006524247.2 → XP_006524310.1  ras/Rap GTPase-activating protein SynGAP isoform X14

      See identical proteins and their annotated locations for XP_006524310.1

      UniProtKB/TrEMBL
      A0A0J9YVH8
      Related
      ENSMUSP00000144666.3, ENSMUST00000201349.6
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1261
      DUF3498; Domain of unknown function (DUF3498)

    7. XM_036160599.1 → XP_036016492.1  ras/Rap GTPase-activating protein SynGAP isoform X14

      UniProtKB/TrEMBL
      A0A0J9YVH8
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1261
      DUF3498; Domain of unknown function (DUF3498)

    8. XM_006524235.2 → XP_006524298.1  ras/Rap GTPase-activating protein SynGAP isoform X1

      UniProtKB/TrEMBL
      A0A2R8VHH2
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1292
      DUF3498; Domain of unknown function (DUF3498)

    9. XM_006524243.2 → XP_006524306.1  ras/Rap GTPase-activating protein SynGAP isoform X12

      UniProtKB/TrEMBL
      J3QQ18
      Related
      ENSMUSP00000141245.3, ENSMUST00000193200.6
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1292
      DUF3498; Domain of unknown function (DUF3498)

    10. XM_006524236.2 → XP_006524299.1  ras/Rap GTPase-activating protein SynGAP isoform X2

      UniProtKB/TrEMBL
      A0A2R8VHH2
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1290
      DUF3498; Domain of unknown function (DUF3498)

    11. XM_030249783.1 → XP_030105643.1  ras/Rap GTPase-activating protein SynGAP isoform X3

      UniProtKB/TrEMBL
      A0A0J9YUM2
      Conserved Domains (4) summary
      cd04013
      Location:252 → 414
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:405 → 728
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:122 → 313
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:718 → 1276
      DUF3498; Domain of unknown function (DUF3498)

    12. XM_006524241.3 → XP_006524304.1  ras/Rap GTPase-activating protein SynGAP isoform X8

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:176 → 338
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:329 → 652
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:46 → 237
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:642 → 1216
      DUF3498; Domain of unknown function (DUF3498)

    13. XM_030249791.1 → XP_030105651.1  ras/Rap GTPase-activating protein SynGAP isoform X21

      Conserved Domains (2) summary
      pfam12004
      Location:116 → 659
      DUF3498; Domain of unknown function (DUF3498)
      cl02569
      Location:1 → 126
      RasGAP; Ras GTPase Activating Domain

    14. XM_036160597.1 → XP_036016490.1  ras/Rap GTPase-activating protein SynGAP isoform X4

      UniProtKB/TrEMBL
      A0A0A6YVS6
      Conserved Domains (4) summary
      cd04013
      Location:224 → 386
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:377 → 700
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:94 → 285
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:690 → 1264
      DUF3498; Domain of unknown function (DUF3498)

    15. XM_006524238.5 → XP_006524301.1  ras/Rap GTPase-activating protein SynGAP isoform X4

      See identical proteins and their annotated locations for XP_006524301.1

      UniProtKB/TrEMBL
      A0A0A6YVS6
      Conserved Domains (4) summary
      cd04013
      Location:224 → 386
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:377 → 700
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:94 → 285
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:690 → 1264
      DUF3498; Domain of unknown function (DUF3498)

    16. XM_030249786.1 → XP_030105646.1  ras/Rap GTPase-activating protein SynGAP isoform X13

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:135 → 297
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:288 → 611
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:5 → 196
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:601 → 1175
      DUF3498; Domain of unknown function (DUF3498)

    17. XM_006524244.5 → XP_006524307.1  ras/Rap GTPase-activating protein SynGAP isoform X13

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:135 → 297
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:288 → 611
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:5 → 196
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:601 → 1175
      DUF3498; Domain of unknown function (DUF3498)

    18. XM_036160600.1 → XP_036016493.1  ras/Rap GTPase-activating protein SynGAP isoform X16

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:135 → 297
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:288 → 611
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:5 → 196
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:601 → 1161
      DUF3498; Domain of unknown function (DUF3498)

    19. XM_006524242.3 → XP_006524305.1  ras/Rap GTPase-activating protein SynGAP isoform X10

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:166 → 328
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:319 → 642
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:36 → 227
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:632 → 1206
      DUF3498; Domain of unknown function (DUF3498)

    20. XM_030249785.2 → XP_030105645.1  ras/Rap GTPase-activating protein SynGAP isoform X11

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:166 → 328
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:319 → 642
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:36 → 227
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:632 → 1192
      DUF3498; Domain of unknown function (DUF3498)

    21. XM_036160598.1 → XP_036016491.1  ras/Rap GTPase-activating protein SynGAP isoform X13

      UniProtKB/TrEMBL
      A0A2S1B6F9
      Conserved Domains (4) summary
      cd04013
      Location:135 → 297
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:288 → 611
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:5 → 196
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:601 → 1175
      DUF3498; Domain of unknown function (DUF3498)

    22. XM_006524239.5 → XP_006524302.1  ras/Rap GTPase-activating protein SynGAP isoform X6

      UniProtKB/TrEMBL
      A0A2R8VH83
      Conserved Domains (4) summary
      cd04013
      Location:193 → 355
      C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
      cd05136
      Location:346 → 669
      RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
      cd13375
      Location:63 → 254
      PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
      pfam12004
      Location:659 → 1233
      DUF3498; Domain of unknown function (DUF3498)

    23. XM_036160601.1 → XP_036016494.1  ras/Rap GTPase-activating protein SynGAP isoform X19

      Conserved Domains (2) summary
      pfam12004
      Location:116 → 691
      DUF3498; Domain of unknown function (DUF3498)
      cl02569
      Location:1 → 126
      RasGAP; Ras GTPase Activating Domain

    24. XM_030249790.1 → XP_030105650.1  ras/Rap GTPase-activating protein SynGAP isoform X20

      Conserved Domains (2) summary
      pfam12004
      Location:116 → 689
      DUF3498; Domain of unknown function (DUF3498)
      cl02569
      Location:1 → 126
      RasGAP; Ras GTPase Activating Domain

    25. XM_006524248.3 → XP_006524311.1  ras/Rap GTPase-activating protein SynGAP isoform X17

      Conserved Domains (2) summary
      pfam12004
      Location:116 → 690
      DUF3498; Domain of unknown function (DUF3498)
      cl02569
      Location:1 → 126
      RasGAP; Ras GTPase Activating Domain

    26. XM_030249788.2 → XP_030105648.1  ras/Rap GTPase-activating protein SynGAP isoform X18

      Conserved Domains (2) summary
      pfam12004
      Location:116 → 676
      DUF3498; Domain of unknown function (DUF3498)
      cl02569
      Location:1 → 126
      RasGAP; Ras GTPase Activating Domain

    RNA

    1. XR_003952116.1 RNA Sequence

    2. XR_003952115.1 RNA Sequence

    3. XR_385324.4 RNA Sequence

    4. XR_003952117.1 RNA Sequence

    5. XR_004939524.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6SEU4.2 GenPept UniProtKB/Swiss-Prot:F6SEU4

    Gene LinkOut

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