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    Vav2 vav 2 oncogene [ Mus musculus (house mouse) ]

    Gene ID: 22325, updated on 27-Nov-2024

    Summary

    Official Symbol
    Vav2provided by MGI
    Official Full Name
    vav 2 oncogeneprovided by MGI
    Primary source
    MGI:MGI:102718
    See related
    Ensembl:ENSMUSG00000009621 AllianceGenome:MGI:102718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vav-2; 2810040F13Rik
    Summary
    This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in spleen adult (RPKM 23.7), duodenum adult (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Vav2 in Genome Data Viewer
    Location:
    2 A3; 2 19.36 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (27152116..27317620, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27262104..27427608, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dopamine beta hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27159262-27159371 Neighboring gene Vav2R10 erythroid cis-regulatory module Neighboring gene Vav2R3 erythroid cis-regulatory module Neighboring gene STARR-seq mESC enhancer starr_04000 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:27269900-27270101 Neighboring gene STARR-seq mESC enhancer starr_04002 Neighboring gene Vav2R7 erythroid cis-regulatory module Neighboring gene Vav2R5 erythroid cis-regulatory module Neighboring gene bromodomain containing 3, opposite strand Neighboring gene microRNA 7578 Neighboring gene bromodomain containing 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    guanine nucleotide exchange factor VAV2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009500.2NP_033526.1  guanine nucleotide exchange factor VAV2

      See identical proteins and their annotated locations for NP_033526.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AI847175, AL772282, BC053060, U37017
      Consensus CDS
      CCDS15827.1
      UniProtKB/Swiss-Prot
      A2AH49, Q60992
      UniProtKB/TrEMBL
      Q7TSI6
      Related
      ENSMUSP00000062782.8, ENSMUST00000056176.8
      Conserved Domains (8) summary
      cd10406
      Location:657759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:809866
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      cd00029
      Location:514561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam00169
      Location:401502
      PH; PH domain
      pfam00621
      Location:197370
      RhoGEF; RhoGEF domain
      pfam11971
      Location:18103
      CAMSAP_CH; CAMSAP CH domain

    RNA

    1. NR_133905.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' exon and contains several additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI847175, AL772282, BC053060
      Related
      ENSMUST00000185188.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      27152116..27317620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497858.3XP_006497921.1  guanine nucleotide exchange factor VAV2 isoform X4

      See identical proteins and their annotated locations for XP_006497921.1

      UniProtKB/TrEMBL
      Q7TSI6
      Conserved Domains (7) summary
      cd10406
      Location:657759
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:780837
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:580639
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:514561
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384506
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18103
      CAMSAP_CH; CAMSAP CH domain
    2. XM_006497856.2XP_006497919.1  guanine nucleotide exchange factor VAV2 isoform X2

      UniProtKB/TrEMBL
      Q7TSI6
      Conserved Domains (7) summary
      cd10406
      Location:662764
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:814871
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:585644
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:197370
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:519566
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:384511
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18103
      CAMSAP_CH; CAMSAP CH domain
    3. XM_006497854.2XP_006497917.1  guanine nucleotide exchange factor VAV2 isoform X1

      UniProtKB/TrEMBL
      Q7TSI6
      Conserved Domains (7) summary
      cd10406
      Location:667769
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:819876
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:590649
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:202375
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:524571
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:389516
      PH_Vav; Vav pleckstrin homology (PH) domain
      pfam11971
      Location:18103
      CAMSAP_CH; CAMSAP CH domain
    4. XM_030249470.2XP_030105330.1  guanine nucleotide exchange factor VAV2 isoform X3

      Conserved Domains (7) summary
      cd10406
      Location:662764
      SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
      cd11977
      Location:814871
      SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
      cd11980
      Location:585644
      SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
      smart00325
      Location:202375
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd00029
      Location:519566
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01223
      Location:389511
      PH_Vav; Vav pleckstrin homology (PH) domain
      cl00030
      Location:71108
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...