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    Sys1 SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 66460, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sys1provided by MGI
    Official Full Name
    SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1913710
    See related
    Ensembl:ENSMUSG00000045503 AllianceGenome:MGI:1913710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610042O14Rik
    Summary
    Predicted to be involved in Golgi to endosome transport; Golgi to plasma membrane protein transport; and protein localization to Golgi apparatus. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human SYS1 (SYS1 golgi trafficking protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 87.4), ovary adult (RPKM 57.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sys1 in Genome Data Viewer
    Location:
    2 H3; 2 85.16 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164297736..164322141)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164456930..164480221)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene matrilin 4 Neighboring gene STARR-positive B cell enhancer ABC_E6015 Neighboring gene recombination signal binding protein for immunoglobulin kappa J region-like Neighboring gene STARR-positive B cell enhancer ABC_E4517 Neighboring gene STARR-positive B cell enhancer ABC_E6016 Neighboring gene STARR-seq mESC enhancer starr_06326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164266728-164266915 Neighboring gene syndecan 4 Neighboring gene STARR-seq mESC enhancer starr_06330 Neighboring gene STARR-positive B cell enhancer ABC_E7884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164286295-164286478 Neighboring gene transformation related protein 53 target 5 Neighboring gene dysbindin domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9539 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class T Neighboring gene STARR-seq mESC enhancer starr_06331 Neighboring gene predicted gene, 36090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Tan GH, et al. Cell Res, 2018 Jan. PMID 29056747, Free PMC Article
    2. A novel mouse Chromosome 2 congenic strain with obesity phenotypes. Diament AL, et al. Mamm Genome, 2004 Jun. PMID 15181537
    3. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
    4. Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation. Ansseau E, et al. PLoS One, 2016. PMID 26816005, Free PMC Article
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein SYS1 homolog
    Names
    Sys1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025575.4 → NP_079851.2  protein SYS1 homolog

      See identical proteins and their annotated locations for NP_079851.2

      Status: VALIDATED

      Source sequence(s)
      AL591478
      Consensus CDS
      CCDS50793.1
      UniProtKB/Swiss-Prot
      Q3UFU1, Q78S06, Q9DAU8
      Related
      ENSMUSP00000072275.5, ENSMUST00000072452.11
      Conserved Domains (1) summary
      pfam09801
      Location:5 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164297736..164322141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162452.1 → XP_036018345.1  protein SYS1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q3UFU1, Q78S06, Q9DAU8
      Conserved Domains (1) summary
      pfam09801
      Location:5 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    2. XM_011239733.3 → XP_011238035.1  protein SYS1 homolog isoform X1

      See identical proteins and their annotated locations for XP_011238035.1

      UniProtKB/Swiss-Prot
      Q3UFU1, Q78S06, Q9DAU8
      Related
      ENSMUSP00000104976.2, ENSMUST00000109352.8
      Conserved Domains (1) summary
      pfam09801
      Location:5 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    3. XM_036162454.1 → XP_036018347.1  protein SYS1 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q3UFU1, Q78S06, Q9DAU8
      Conserved Domains (1) summary
      pfam09801
      Location:5 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    4. XM_011239732.4 → XP_011238034.1  protein SYS1 homolog isoform X1

      See identical proteins and their annotated locations for XP_011238034.1

      UniProtKB/Swiss-Prot
      Q3UFU1, Q78S06, Q9DAU8
      Conserved Domains (1) summary
      pfam09801
      Location:5 → 148
      SYS1; Integral membrane protein S linking to the trans Golgi network

    RNA

    1. XR_003953683.1 RNA Sequence

    2. XR_374503.3 RNA Sequence

    3. XR_374501.3 RNA Sequence

      Related
      ENSMUST00000138268.8

    4. XR_866332.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78S06.1 GenPept UniProtKB/Swiss-Prot:Q78S06

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