Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufb5provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit B5provided by MGI
Primary source: MGI:MGI:1913296
See related: Ensembl:ENSMUSG00000027673 AllianceGenome:MGI:1913296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SGDH; CI-SGDH; 0610007D05Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in pancreas epithelium. Orthologous to human NDUFB5 (NADH:ubiquinone oxidoreductase subunit B5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 156.3), adrenal adult (RPKM 105.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 15.85 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (32791206..32805708)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (32737057..32751559)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.
Title: METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ndufb5 (e-PCR), detects polymorphism
- UniSTS:546889

AU015782 (e-PCR)
- UniSTS:207477

NoName (e-PCR)
- UniSTS:234655

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5; NADH-ubiquinone oxidoreductase SGDH subunit; complex I-SGDH

NP_079592.2

EC 1.6.99.3

EC 7.1.1.2

XP_006535577.1

EC 1.6.99.3

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025316.2 → NP_079592.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor

See identical proteins and their annotated locations for NP_079592.2

Status: VALIDATED

Source sequence(s)

AK004372

Consensus CDS

CCDS17300.1

UniProtKB/Swiss-Prot

Q9CQH3

UniProtKB/TrEMBL

Q8BU20

Related

ENSMUSP00000114963.2, ENSMUST00000127477.8

Conserved Domains (1) summary

pfam09781
Location:1 → 188

NDUF_B5; NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit