Parp11 poly (ADP-ribose) polymerase family, member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp11provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 11provided by MGI
Primary source: MGI:MGI:2141505
See related: Ensembl:ENSMUSG00000037997 AllianceGenome:MGI:2141505
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HIN1L; ARTD11; PARP-11; 5330431N24Rik
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Acts upstream of or within nuclear envelope organization. Predicted to be located in cytosol; nuclear body; and nuclear envelope. Predicted to be part of nuclear pore. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; reproductive system; and thymus. Orthologous to human PARP11 (poly(ADP-ribose) polymerase family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in whole brain E14.5 (RPKM 10.7), CNS E14 (RPKM 10.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F3; 6 62.39 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (127423803..127491200)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (127446830..127514233)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest that PARP11 is involved in regulating the IFN-I signaling pathway and antiviral efficacy by targeting beta-TrCP and degrading IFNAR1.
Title: ADP-ribosyltransferase PARP11 modulates the interferon antiviral response by mono-ADP-ribosylating the ubiquitin E3 ligase β-TrCP.
PARP11 is a novel enzyme important for proper sperm head shaping and identifies it as a potential factor involved in idiopathic mammalian teratozoospermia.
Title: Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear envelope organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP11

Names: ADP-ribosyltransferase diphtheria toxin-like 11; poly [ADP-ribose] polymerase 11

NP_001333441.1

EC 2.4.2.30

NP_001333442.1

EC 2.4.2.30

NP_001349115.1

EC 2.4.2.30

NP_001349116.1

EC 2.4.2.30

NP_852067.1

EC 2.4.2.30

XP_006505294.1

EC 2.4.2.30

XP_006505295.1

EC 2.4.2.30

XP_006505296.1

EC 2.4.2.30

XP_006505297.1

EC 2.4.2.30

XP_017176774.1

EC 2.4.2.30

XP_017176775.1

EC 2.4.2.30

XP_030110895.1

EC 2.4.2.30

XP_030110897.1

EC 2.4.2.30

XP_030110898.1

EC 2.4.2.30

XP_030110899.1

EC 2.4.2.30

XP_030110900.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346512.1 → NP_001333441.1 protein mono-ADP-ribosyltransferase PARP11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).

Source sequence(s)

AC121565, AK030559, BE135078, CF739218

Consensus CDS

CCDS85162.1

UniProtKB/Swiss-Prot

Q8CFF0

UniProtKB/TrEMBL

Q8BML7

Conserved Domains (1) summary

cd01439
Location:111 → 247

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
NM_001346513.1 → NP_001333442.1 protein mono-ADP-ribosyltransferase PARP11 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).

Source sequence(s)

AK151393, BE135078

Consensus CDS

CCDS85162.1

UniProtKB/Swiss-Prot

Q8CFF0

Related

ENSMUSP00000107810.2, ENSMUST00000112191.8

Conserved Domains (1) summary

cd01439
Location:111 → 247

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
NM_001362186.1 → NP_001349115.1 protein mono-ADP-ribosyltransferase PARP11 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon in the 5' end compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC121565, AC173480, CD349558

Conserved Domains (1) summary

cd01439
Location:120 → 256

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
NM_001362187.1 → NP_001349116.1 protein mono-ADP-ribosyltransferase PARP11 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the 5' end and uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC121565, AC173480

UniProtKB/TrEMBL

Q8BML7

Conserved Domains (1) summary

cd01439
Location:77 → 213

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
NM_181402.4 → NP_852067.1 protein mono-ADP-ribosyltransferase PARP11 isoform 1

See identical proteins and their annotated locations for NP_852067.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC121565, AC173480

Consensus CDS

CCDS20565.1

UniProtKB/Swiss-Prot

Q3UAF2, Q3UZR7, Q8CFF0

Related

ENSMUSP00000036127.6, ENSMUST00000039680.7

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:194 → 330

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

127423803..127491200

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505233.5 → XP_006505296.1 protein mono-ADP-ribosyltransferase PARP11 isoform X2

See identical proteins and their annotated locations for XP_006505296.1

UniProtKB/Swiss-Prot

Q3UAF2, Q3UZR7, Q8CFF0

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:194 → 330

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_006505232.5 → XP_006505295.1 protein mono-ADP-ribosyltransferase PARP11 isoform X2

See identical proteins and their annotated locations for XP_006505295.1

UniProtKB/Swiss-Prot

Q3UAF2, Q3UZR7, Q8CFF0

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:194 → 330

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_017321286.3 → XP_017176775.1 protein mono-ADP-ribosyltransferase PARP11 isoform X5

Conserved Domains (2) summary

smart00678
Location:34 → 114

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam00644
Location:147 → 190

PARP; Poly(ADP-ribose) polymerase catalytic domain
XM_030255040.2 → XP_030110900.1 protein mono-ADP-ribosyltransferase PARP11 isoform X6

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam00644
Location:140 → 183

PARP; Poly(ADP-ribose) polymerase catalytic domain
XM_030255039.1 → XP_030110899.1 protein mono-ADP-ribosyltransferase PARP11 isoform X6

Related

ENSMUSP00000107812.2, ENSMUST00000112193.8

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

pfam00644
Location:140 → 183

PARP; Poly(ADP-ribose) polymerase catalytic domain
XM_006505231.4 → XP_006505294.1 protein mono-ADP-ribosyltransferase PARP11 isoform X2

See identical proteins and their annotated locations for XP_006505294.1

UniProtKB/Swiss-Prot

Q3UAF2, Q3UZR7, Q8CFF0

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:194 → 330

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_017321285.3 → XP_017176774.1 protein mono-ADP-ribosyltransferase PARP11 isoform X1

Conserved Domains (2) summary

smart00678
Location:34 → 114

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:201 → 337

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_030255035.1 → XP_030110895.1 protein mono-ADP-ribosyltransferase PARP11 isoform X4

UniProtKB/TrEMBL

Q8BML7

Conserved Domains (1) summary

cd01439
Location:77 → 213

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_006505234.4 → XP_006505297.1 protein mono-ADP-ribosyltransferase PARP11 isoform X3

See identical proteins and their annotated locations for XP_006505297.1

Conserved Domains (1) summary

cd01439
Location:120 → 256

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_030255037.1 → XP_030110897.1 protein mono-ADP-ribosyltransferase PARP11 isoform X4

UniProtKB/TrEMBL

Q8BML7

Conserved Domains (1) summary

cd01439
Location:77 → 213

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_030255038.1 → XP_030110898.1 protein mono-ADP-ribosyltransferase PARP11 isoform X4

UniProtKB/TrEMBL

Q8BML7

Conserved Domains (1) summary

cd01439
Location:77 → 213

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...