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    Defb14 defensin beta 14 [ Mus musculus (house mouse) ]

    Gene ID: 244332, updated on 9-Dec-2024

    Summary

    Official Symbol
    Defb14provided by MGI
    Official Full Name
    defensin beta 14provided by MGI
    Primary source
    MGI:MGI:2675345
    See related
    Ensembl:ENSMUSG00000046354 AllianceGenome:MGI:2675345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-14
    Summary
    Enables chemoattractant activity. Acts upstream of or within cell chemotaxis and defense response to bacterium. Predicted to be active in extracellular space. Is expressed in skin. Orthologous to human DEFB103A (defensin beta 103A) and DEFB103B (defensin beta 103B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 5.3) and testis adult (RPKM 2.8) See more
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    Genomic context

    See Defb14 in Genome Data Viewer
    Location:
    8 A1.3; 8 10.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (19213172..19245342)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (19160244..19195309)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 11A Neighboring gene predicted gene, 53432 Neighboring gene predicted gene, 39139 Neighboring gene STARR-seq mESC enhancer starr_20861 Neighboring gene defensin beta 4 Neighboring gene defensin, alpha, pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR6 chemokine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemoattractant activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183026.3NP_898847.1  beta-defensin 14 precursor

      See identical proteins and their annotated locations for NP_898847.1

      Status: VALIDATED

      Source sequence(s)
      AC116394
      Consensus CDS
      CCDS40253.1
      UniProtKB/Swiss-Prot
      Q14BD1, Q7TNV9
      Related
      ENSMUSP00000062781.4, ENSMUST00000052601.4
      Conserved Domains (1) summary
      pfam00711
      Location:3064
      Defensin_beta; Beta defensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      19213172..19245342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508792.4XP_006508855.1  beta-defensin 14 isoform X1

      See identical proteins and their annotated locations for XP_006508855.1

      UniProtKB/Swiss-Prot
      Q14BD1, Q7TNV9
      Conserved Domains (1) summary
      pfam00711
      Location:3064
      Defensin_beta; Beta defensin
    2. XM_006508794.4XP_006508857.1  beta-defensin 14 isoform X1

      See identical proteins and their annotated locations for XP_006508857.1

      UniProtKB/Swiss-Prot
      Q14BD1, Q7TNV9
      Conserved Domains (1) summary
      pfam00711
      Location:3064
      Defensin_beta; Beta defensin
    3. XM_006508795.4XP_006508858.1  beta-defensin 14 isoform X1

      See identical proteins and their annotated locations for XP_006508858.1

      UniProtKB/Swiss-Prot
      Q14BD1, Q7TNV9
      Conserved Domains (1) summary
      pfam00711
      Location:3064
      Defensin_beta; Beta defensin
    4. XM_006508797.4XP_006508860.1  beta-defensin 14 isoform X1

      See identical proteins and their annotated locations for XP_006508860.1

      UniProtKB/Swiss-Prot
      Q14BD1, Q7TNV9
      Conserved Domains (1) summary
      pfam00711
      Location:3064
      Defensin_beta; Beta defensin