wwp-1 E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wwp-1
Official Full Name: E3 ubiquitin-protein ligase wwp-1
Primary source: WormBase:WBGene00007009
Locus tag: CELE_Y65B4BR.4
See related: AllianceGenome:WB:WBGene00007009
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Is expressed in several structures, including coelomocyte; intestine; nervous system; rectum; and vulval muscle. Orthologous to several human genes including WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wwp-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (537122..542204)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WWP-1 directly interacts with KLF-1 and mediates multiple monoubiquitylation of KLF-1 in vitro and in cellulo. The data support a model in which modulation of KLF-1 by WWP-1 regulates diet-restriction-induced longevity.
Title: A Krüppel-like factor downstream of the E3 ligase WWP-1 mediates dietary-restriction-induced longevity in Caenorhabditis elegans.
WWP-1 and DAF-16 function in parallel within the fundamental DAF-2 insulin/IGF-1 signaling network to regulate fundamental cellular responses in C. elegans
Title: WWP-1 is a novel modulator of the DAF-2 insulin-like signaling network involved in pore-forming toxin cellular defenses in Caenorhabditis elegans.
results indicate that WWP-1 and UBC-18 function to ubiquitinate substrates that regulate diet-restriction-induced longevity
Title: A conserved ubiquitination pathway determines longevity in response to diet restriction.
WWP-1 is the putative E3 ubiquitin ligase mediating the degradation of the large RNA polymerase II (RNA pol II) subunit, AMA-1 under UV irradiation.
Title: Nucleotide excision repair and the degradation of RNA pol II by the Caenorhabditis elegans XPA and Rsp5 orthologues, RAD-3 and WWP-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y65B4B_10.a (e-PCR)
- UniSTS:323215

Y65B4B_10.b (e-PCR)
- UniSTS:323216

Y65B4B_11.a (e-PCR)
- UniSTS:323218

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity, acting on a protein	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase wwp-1

NP_001293271.1

Confirmed by transcript evidence

NP_001293272.1

Confirmed by transcript evidence

NP_740775.1

Confirmed by transcript evidence

NP_740776.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

537122..542204

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170794.7 → NP_740775.1 E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740775.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95XU3, Q9N2Z7, V6CJJ8, V6CLY4

Conserved Domains (3) summary

COG5021
Location:251 → 794

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

pfam00397
Location:221 → 250

WW; WW domain

cl14603
Location:29 → 147

C2; C2 domain
NM_171831.4 → NP_740776.1 E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_740776.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95XU3

Conserved Domains (5) summary

smart00456
Location:325 → 357

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:461 → 789

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:438 → 790

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam00397
Location:255 → 284

WW; WW domain

cl14603
Location:29 → 147

C2; C2 domain
NM_001306342.3 → NP_001293271.1 E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293271.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CLY4

Conserved Domains (1) summary

COG5021
Location:39 → 507

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
NM_001306343.3 → NP_001293272.1 E3 ubiquitin-protein ligase wwp-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293272.1

Status: REVIEWED

UniProtKB/TrEMBL

V6CJJ8

Conserved Domains (1) summary

COG5021
Location:39 → 505

HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]