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    tppp-1 Tubulin polymerization-promoting protein homolog [ Caenorhabditis elegans ]

    Gene ID: 171948, updated on 9-Dec-2024

    Summary

    Official Symbol
    tppp-1
    Official Full Name
    Tubulin polymerization-promoting protein homolog
    Primary source
    WormBase:WBGene00016321
    Locus tag
    CELE_C32E8.3
    See related
    AllianceGenome:WB:WBGene00016321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in microtubule bundle formation; microtubule polymerization; and positive regulation of protein polymerization. Predicted to colocalize with microtubule. Orthologous to human TPPP (tubulin polymerization promoting protein); TPPP2 (tubulin polymerization promoting protein family member 2); and TPPP3 (tubulin polymerization promoting protein family member 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See tppp-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (3786588..3787496)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene FHA domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Large ribosomal subunit protein eL13 Neighboring gene SSD domain-containing protein

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    colocalizes_with microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Tubulin polymerization-promoting protein homolog
    NP_491219.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3786588..3787496
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058818.4NP_491219.1  Tubulin polymerization-promoting protein homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91127
      Conserved Domains (1) summary
      pfam05517
      Location:18175
      p25-alpha; p25-alpha