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    rol-6 Cuticle collagen rol-6 [ Caenorhabditis elegans ]

    Gene ID: 174397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rol-6
    Official Full Name
    Cuticle collagen rol-6
    Primary source
    WormBase:WBGene00004397
    Locus tag
    CELE_T01B7.7
    See related
    AllianceGenome:WB:WBGene00004397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    A structural constituent of collagen and cuticulin-based cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Located in collagen and cuticulin-based cuticle extracellular matrix. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 5. Orthologous to human COLQ (collagen like tail subunit of asymmetric acetylcholinesterase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rol-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (8733050..8734239)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intrinsically Disordered Protein, class B Neighboring gene MAP kinase-activated protein kinase mak-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemotaxis based enrichment for transgenic animals containing the rol-6 marker. Carter J, et al. MicroPubl Biol, 2018 Jun 7. PMID 32550398, Free PMC Article
    2. Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. Mello CC, et al. EMBO J, 1991 Dec. PMID 1935914, Free PMC Article
    3. Expressional artifact caused by a co-injection marker rol-6 in C. elegans. Jin H, et al. PLoS One, 2019. PMID 31800569, Free PMC Article
    4. Generation of stable transgenic C. elegans using microinjection. Berkowitz LA, et al. J Vis Exp, 2008 Aug 15. PMID 19066505, Free PMC Article
    5. Genetic mapping and manipulation: chapter 7--Making compound mutants. Fay D. WormBook, 2006 Jun 14. PMID 18050457, Free PMC Article

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of collagen and cuticulin-based cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of collagen and cuticulin-based cuticle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen and cuticulin-based cuticle extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen and cuticulin-based cuticle extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cuticle collagen rol-6
    NP_495858.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8733050..8734239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063457.4 → NP_495858.1  Cuticle collagen rol-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495858.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P20784
      Conserved Domains (2) summary
      pfam01391
      Location:194 → 242
      Collagen; Collagen triple helix repeat (20 copies)
      pfam01484
      Location:9 → 57
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20784.1

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