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    phg-1 Growth arrest-specific protein 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 185024, updated on 9-Dec-2024

    Summary

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    Official Symbol
    phg-1
    Official Full Name
    Growth arrest-specific protein 1 homolog
    Primary source
    WormBase:WBGene00004017
    Locus tag
    CELE_F27E5.4
    See related
    AllianceGenome:WB:WBGene00004017
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of cell cycle G1/S phase transition. Located in plasma membrane. Is expressed in muscle cell and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See phg-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (10137658..10139216)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative G-protein coupled receptor F27E5.5 Neighboring gene Uncharacterized protein Neighboring gene putative acid ceramidase Neighboring gene Uncharacterized protein Neighboring gene Paired box protein 3 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Derry WB, et al. Cell Death Differ, 2007 Apr. PMID 17186023
    2. Cloning and characterization of the C. elegans gas1 homolog: phas-1. Agostoni E, et al. Biochim Biophys Acta, 2002 Feb 20. PMID 11955608
    3. C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless. Pan CL, et al. Dev Cell, 2008 Jan. PMID 18160346, Free PMC Article
    4. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
    5. Transcriptomic Analysis Reveals JAK2/MPL-Independent Effects of Calreticulin Mutations in a C. elegans Model. Guijarro-Hernández A, et al. Cells, 2023 Jan 2. PMID 36611979, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Growth arrest-specific protein 1 homolog
    NP_496186.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10137658..10139216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063785.5 → NP_496186.2  Growth arrest-specific protein 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496186.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09553
      Conserved Domains (1) summary
      smart00907
      Location:24 → 86
      GDNF; GDNF/GAS1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09553.2

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