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    tbc-20 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-20
    Official Full Name
    Rab-GAP TBC domain-containing protein
    Primary source
    WormBase:WBGene00013196
    Locus tag
    CELE_Y54E2A.12
    See related
    AllianceGenome:WB:WBGene00013196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Warburg micro syndrome 4. Orthologous to human TBC1D20 (TBC1 domain family member 20). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (14798472..14800971)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Eukaryotic translation initiation factor 3 subunit B Neighboring gene Receptor expression-enhancing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rab-GAP TBC domain-containing protein
    NP_001293538.1
    • Confirmed by transcript evidence
    NP_497068.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14798472..14800971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064667.5 → NP_497068.2  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497068.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWI2
      Conserved Domains (1) summary
      cl02495
      Location:147 → 318
      RabGAP-TBC; Rab-GTPase-TBC domain

    2. NM_001306609.3 → NP_001293538.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293538.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB10
    Nucleotide Protein
    Heading Accession and Version

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