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    acs-19 Acetyl-coenzyme A synthetase [ Caenorhabditis elegans ]

    Gene ID: 175500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acs-19
    Official Full Name
    Acetyl-coenzyme A synthetase
    Primary source
    WormBase:WBGene00007969
    Locus tag
    CELE_C36A4.9
    See related
    AllianceGenome:WB:WBGene00007969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acetate-CoA ligase activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and regulation of response to oxidative stress. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acs-19 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (3864489..3867098)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Breast cancer type 1 susceptibility protein homolog;RING-type E3 ubiquitin transferase BRCA1 Neighboring gene ncRNA Neighboring gene Large ribosomal subunit protein uL3 Neighboring gene ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase;NAD(+) hydrolase tir-1;Sterile alpha and TIR motif-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bacterial vitamin B(12) production enhances nematode predatory behavior. Akduman N, et al. ISME J, 2020 Jun. PMID 32152389, Free PMC Article
    2. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
    3. A metabolic regulatory network for the Caenorhabditis elegans intestine. Bhattacharya S, et al. iScience, 2022 Aug 19. PMID 35847555, Free PMC Article
    4. Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Segref A, et al. Cell Metab, 2014 Apr 1. PMID 24703696
    5. Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Oh SW, et al. Nat Genet, 2006 Feb. PMID 16380712

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CoA-ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-thiol ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from acetate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Acetyl-coenzyme A synthetase
    NP_001021205.1
    • Confirmed by transcript evidence
    NP_001021206.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      3864489..3867098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026035.4 → NP_001021206.1  Acetyl-coenzyme A synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q65ZB8
      Conserved Domains (2) summary
      cd05966
      Location:34 → 655
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PRK00174
      Location:11 → 670
      PRK00174; acetyl-CoA synthetase; Provisional

    2. NM_001026034.6 → NP_001021205.1  Acetyl-coenzyme A synthetase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18496
      Conserved Domains (2) summary
      cd05966
      Location:44 → 665
      ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
      PRK00174
      Location:21 → 680
      PRK00174; acetyl-CoA synthetase; Provisional
    Nucleotide Protein
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