wdr-4 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: wdr-4
Official Full Name: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit
Primary source: WormBase:WBGene00022420
Locus tag: CELE_Y102E9.2
See related: AllianceGenome:WB:WBGene00022420
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in tRNA modification. Predicted to be part of tRNA methyltransferase complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and microcephaly, growth deficiency, seizures, and brain malformations. Orthologous to human WDR4 (WD repeat domain 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wdr-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (6725789..6728059)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y102E9.2 (e-PCR)
- UniSTS:311175

F37A4.1 (e-PCR)
- UniSTS:310166

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit

NP_001122722.1

Confirmed by transcript evidence

NP_498476.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

6725789..6728059

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066075.5 → NP_498476.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498476.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23232

Conserved Domains (3) summary

COG2319
Location:162 → 300

WD40; WD40 repeat [General function prediction only]

sd00039
Location:72 → 109

7WD40; WD40 repeat [structural motif]

cl02567
Location:6 → 236

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001129250.3 → NP_001122722.1 tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122722.1

Status: REVIEWED

UniProtKB/TrEMBL

G8XYY6

Conserved Domains (3) summary

COG2319
Location:60 → 338

WD40; WD40 repeat [General function prediction only]

sd00039
Location:72 → 109

7WD40; WD40 repeat [structural motif]

cl02567
Location:6 → 239

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...