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    pps-1 Sulfate adenylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 177893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pps-1
    Official Full Name
    Sulfate adenylyltransferase
    Primary source
    WormBase:WBGene00004091
    Locus tag
    CELE_T14G10.1
    See related
    AllianceGenome:WB:WBGene00004091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable adenylylsulfate kinase activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Predicted to be located in nucleus. Is expressed in epithelial cell; intestine; nervous system; and pharyngeal gland cell. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pps-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (10162006..10164390)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transthyretin-like family protein Neighboring gene ncRNA Neighboring gene Rap guanine nucleotide exchange factor;Rap guanine nucleotide exchange factor 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) synthases, naturally fragile enzymes specifically stabilized by nucleotide binding. van den Boom J, et al. J Biol Chem, 2012 May 18. PMID 22451673, Free PMC Article
    2. Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans. Dejima K, et al. J Biol Chem, 2006 Apr 21. PMID 16497669
    3. Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data. Ruzanov P, et al. BMC Genomics, 2007 Nov 30. PMID 18053145, Free PMC Article
    4. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
    5. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Xia Q, et al. Redox Biol, 2023 Apr. PMID 36791646, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. pps-1 is expressed in the epidermis and several gland cells but not in neurons and muscles, indicating that PAPS in the neurons and muscles is provided by other cells
      Title: Essential roles of 3'-phosphoadenosine 5'-phosphosulfate synthase in embryonic and larval development of the nematode Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sulfate adenylyltransferase
    NP_001293960.1
    • Confirmed by transcript evidence
    NP_501857.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10162006..10164390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001307031.3 → NP_001293960.1  Sulfate adenylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293960.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A061AE05, Q22501
      Conserved Domains (3) summary
      cd00517
      Location:263 → 646
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:237 → 644
      sopT; ATP sulphurylase
      pfam01583
      Location:55 → 212
      APS_kinase; Adenylylsulphate kinase

    2. NM_069456.5 → NP_501857.1  Sulfate adenylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22501
      Conserved Domains (3) summary
      cd00517
      Location:261 → 644
      ATPS; ATP-sulfurylase
      TIGR00339
      Location:235 → 642
      sopT; ATP sulphurylase
      pfam01583
      Location:55 → 210
      APS_kinase; Adenylylsulphate kinase
    Nucleotide Protein
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