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    dpy-4 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178414, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpy-4
    Official Full Name
    Nematode cuticle collagen N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00001066
    Locus tag
    CELE_Y41E3.2
    See related
    AllianceGenome:WB:WBGene00001066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cuticle. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in several diseases, including atherosclerosis; brain small vessel disease 2; osteochondrodysplasia (multiple); porencephaly; and uterine fibroid. Orthologous to human COL4A2 (collagen type IV alpha 2 chain); COL9A1 (collagen type IX alpha 1 chain); and COL27A1 (collagen type XXVII alpha 1 chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dpy-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (14985543..14986784, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene GB1/RHD3-type G domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The origin of footprints of the Tc1 transposon of Caenorhabditis elegans. Plasterk RH. EMBO J, 1991 Jul. PMID 1646714, Free PMC Article
    2. Formaldehyde mutagenesis in the nematode Caenorhabditis elegans. Moerman DG, et al. Mutat Res, 1981 Feb. PMID 7207485
    3. A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein. Chen W, et al. J Biol Chem, 1993 Jan 5. PMID 7677998
    4. Control of cell fate in C. elegans by a GLP-1 peptide consisting primarily of ankyrin repeats. Roehl H, et al. Nature, 1993 Aug 12. PMID 8350921
    5. Mutations in the sup-38 gene of Caenorhabditis elegans suppress muscle-attachment defects in unc-52 mutants. Gilchrist EJ, et al. Genetics, 1992 Oct. PMID 1427037, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cuticle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nematode cuticle collagen N-terminal domain-containing protein
    NP_502808.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14985543..14986784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070407.4 → NP_502808.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502808.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62432
      Conserved Domains (2) summary
      pfam01391
      Location:226 → 269
      Collagen; Collagen triple helix repeat (20 copies)
      smart01088
      Location:12 → 64
      Col_cuticle_N; Nematode cuticle collagen N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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