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    nas-6 Metalloendopeptidase;Zinc metalloproteinase nas-6 [ Caenorhabditis elegans ]

    Gene ID: 181796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nas-6
    Official Full Name
    Metalloendopeptidase;Zinc metalloproteinase nas-6
    Primary source
    WormBase:WBGene00003525
    Locus tag
    CELE_4R79.1
    See related
    AllianceGenome:WB:WBGene00003525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in nematode pharyngeal pumping and pharynx development. Predicted to be located in extracellular region. Is expressed in body wall musculature; hyp7 syncytium; intestine; mc2; and pharyngeal muscle cell. Orthologous to human MEP1A (meprin A subunit alpha) and MEP1B (meprin A subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nas-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    9
    Sequence:
    Chromosome: IV; NC_003282.8 (17486842..17490779, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Putative glucosylceramidase 3 Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-44 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-option of an Astacin Metalloprotease Is Associated with an Evolutionarily Novel Feeding Morphology in a Predatory Nematode. Ishita Y, et al. Mol Biol Evol, 2023 Dec 1. PMID 38105444, Free PMC Article
    2. Characterization of the astacin family of metalloproteases in C. elegans. Park JO, et al. BMC Dev Biol, 2010 Jan 28. PMID 20109220, Free PMC Article
    3. The astacin protein family in Caenorhabditis elegans. Möhrlen F, et al. Eur J Biochem, 2003 Dec. PMID 14653817
    4. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
    5. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Metalloendopeptidase;Zinc metalloproteinase nas-6
    NP_001040902.1
    • Confirmed by transcript evidence
    NP_001040903.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      17486842..17490779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047437.2 → NP_001040902.1  Zinc metalloproteinase nas-6 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7Z0N6, Q9U3S9
      Conserved Domains (3) summary
      cd04280
      Location:83 → 263
      ZnMc_astacin_like; Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to ...
      pfam01400
      Location:80 → 265
      Astacin; Astacin (Peptidase family M12A)
      pfam01549
      Location:299 → 334
      ShK; ShK domain-like

    2. NM_001047438.2 → NP_001040903.1  Metalloendopeptidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2HQL9
      Conserved Domains (2) summary
      pfam01549
      Location:135 → 170
      ShK; ShK domain-like
      cl00064
      Location:1 → 99
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    RNA

    1. NR_132470.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U3S9.2

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