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    Tox2 TOX high mobility group box family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 269389, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tox2provided by MGI
    Official Full Name
    TOX high mobility group box family member 2provided by MGI
    Primary source
    MGI:MGI:3611233
    See related
    Ensembl:ENSMUSG00000074607 AllianceGenome:MGI:3611233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gcx1; RxHMG1
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; chromatin DNA binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; lens epithelium; notochord; retina; and spleen. Orthologous to human TOX2 (TOX high mobility group box family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 36.7), mammary gland adult (RPKM 15.2) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tox2 in Genome Data Viewer
    Location:
    2 H3; 2 84.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163045047..163166092)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163203058..163324172)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene gametocyte specific factor 1-like Neighboring gene predicted gene 11454 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:162990282-162990435 Neighboring gene VISTA enhancer mm1561 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:163054873-163055132 Neighboring gene VISTA enhancer mm1646 Neighboring gene junctophilin 2 Neighboring gene predicted gene, 35750 Neighboring gene STARR-seq mESC enhancer starr_06306 Neighboring gene STARR-seq mESC enhancer starr_06307 Neighboring gene STARR-positive B cell enhancer ABC_E2651 Neighboring gene RIKEN cDNA 2900093K20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1608 Neighboring gene oxidative stress responsive serine rich 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut. Das A, et al. Immunity, 2024 May 14. PMID 38677292,
    2. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Liang S, et al. Mol Vis, 2004 Oct 8. PMID 15496829
    3. TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion. Seo H, et al. Proc Natl Acad Sci U S A, 2019 Jun 18. PMID 31152140, Free PMC Article
    4. Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells. Kajitani T, et al. Endocrinology, 2004 May. PMID 14764631
    5. The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility. Xu W, et al. Immunity, 2019 Nov 19. PMID 31732165

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.
      Title: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut.
    2. Tox2(-/-) mice exhibited defective Tfh differentiation, and inhibition of both Tox2 and the related transcription factor Tox abolished Tfh differentiation. Thus, a Tox2-Bcl6 axis establishes a transcriptional feed-forward loop that promotes the Tfh program.
      Title: The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.
    3. Identification and functional analysis of the rat Gcx1 ortholog.
      Title: Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TOX high mobility group box family member 2
    Names
    granulosa cell HMG-box protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098799.3 → NP_001092269.1  TOX high mobility group box family member 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL589876
      Consensus CDS
      CCDS50790.1
      UniProtKB/TrEMBL
      A2A472, E9Q0B9
      Related
      ENSMUSP00000126243.2, ENSMUST00000165937.8
      Conserved Domains (1) summary
      cd00084
      Location:253 → 318
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    2. NM_001363063.2 → NP_001349992.1  TOX high mobility group box family member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:204 → 269
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    3. NM_001363064.2 → NP_001349993.1  TOX high mobility group box family member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:204 → 269
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    4. NM_001372575.1 → NP_001359504.1  TOX high mobility group box family member 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:246 → 311
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    5. NM_001372576.1 → NP_001359505.1  TOX high mobility group box family member 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      Consensus CDS
      CCDS89577.1
      UniProtKB/TrEMBL
      A2A472, A2A473
      Related
      ENSMUSP00000105055.3, ENSMUST00000109428.9
      Conserved Domains (1) summary
      cd00084
      Location:246 → 311
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    6. NM_001372577.1 → NP_001359506.1  TOX high mobility group box family member 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL589876
      UniProtKB/TrEMBL
      A2A472
      Related
      ENSMUSP00000096710.4, ENSMUST00000099110.10
      Conserved Domains (1) summary
      cd00084
      Location:253 → 318
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    7. NM_001372578.2 → NP_001359507.1  TOX high mobility group box family member 2 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) encodes the longest isoform (7).
      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:272 → 337
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    8. NM_001372579.1 → NP_001359508.1  TOX high mobility group box family member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:204 → 269
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    9. NM_001372580.2 → NP_001359509.1  TOX high mobility group box family member 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472
      Conserved Domains (1) summary
      cd00084
      Location:204 → 269
      HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

    10. NM_001407351.1 → NP_001394280.1  TOX high mobility group box family member 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    11. NM_001407352.1 → NP_001394281.1  TOX high mobility group box family member 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    12. NM_001407353.1 → NP_001394282.1  TOX high mobility group box family member 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    13. NM_001407354.1 → NP_001394283.1  TOX high mobility group box family member 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    14. NM_001407355.1 → NP_001394284.1  TOX high mobility group box family member 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    15. NM_001407356.1 → NP_001394285.1  TOX high mobility group box family member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589876
      UniProtKB/TrEMBL
      A2A472

    16. NM_001407357.1 → NP_001394286.1  TOX high mobility group box family member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589874, AL589876
      UniProtKB/TrEMBL
      A2A472

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      163045047..163166092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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