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    SVOPL SVOP like [ Homo sapiens (human) ]

    Gene ID: 136306, updated on 3-Dec-2024

    Summary

    Official Symbol
    SVOPLprovided by HGNC
    Official Full Name
    SVOP likeprovided by HGNC
    Primary source
    HGNC:HGNC:27034
    See related
    Ensembl:ENSG00000157703 MIM:611700; AllianceGenome:HGNC:27034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLC22B5
    Summary
    The protein encoded by this gene is thought to be a member of solute carrier family 22, which includes transmembrane proteins that transport toxins and drugs from the body. This gene is a paralog of the SVOP gene that encodes synaptic vesicle 2-related protein. [provided by RefSeq, Sep 2016]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See SVOPL in Genome Data Viewer
    Location:
    7q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (138594285..138701362, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (139903966..140013811, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138279030..138386107, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 24 Neighboring gene RPS3A pseudogene 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26743 Neighboring gene uncharacterized LOC124901755 Neighboring gene Sharpr-MPRA regulatory region 10989 Neighboring gene small nucleolar RNA SNORA40 Neighboring gene ribosomal protein L21 pseudogene 73 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:138352744-138353325 Neighboring gene ribosomal protein L17 pseudogene 27 Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 2 Neighboring gene ATPase H+ transporting V0 subunit a4 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:138429227-138429398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138434906-138435708 Neighboring gene MPRA-validated peak6777 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138458197-138458700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:138458701-138459203 Neighboring gene Sharpr-MPRA regulatory region 1249 Neighboring gene transmembrane protein 213

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC46715

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative transporter SVOPL
    Names
    SV2 related protein homolog-like
    solute carrier family 22 member B5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051552.1 RefSeqGene

      Range
      5186..112263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1103

    mRNA and Protein(s)

    1. NM_001139456.2NP_001132928.1  putative transporter SVOPL isoform 1

      See identical proteins and their annotated locations for NP_001132928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC013429, AC020983
      Consensus CDS
      CCDS47721.1
      UniProtKB/Swiss-Prot
      Q8N434
      Related
      ENSP00000501457.1, ENST00000674285.1
      Conserved Domains (2) summary
      cd06174
      Location:51480
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00895
      Location:34454
      2A0115; benzoate transport
    2. NM_001331192.1NP_001318121.1  putative transporter SVOPL isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC013429, AC020983
      Conserved Domains (1) summary
      cl26863
      Location:2397
      Sugar_tr; Sugar (and other) transporter
    3. NM_174959.3NP_777619.1  putative transporter SVOPL isoform 2

      See identical proteins and their annotated locations for NP_777619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL704123, BC036796, BX349158
      Consensus CDS
      CCDS5848.1
      UniProtKB/TrEMBL
      C9JVJ9
      Related
      ENSP00000417018.1, ENST00000436657.5
      Conserved Domains (1) summary
      cl26863
      Location:6336
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      138594285..138701362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515797.3XP_011514099.1  putative transporter SVOPL isoform X3

      See identical proteins and their annotated locations for XP_011514099.1

      UniProtKB/TrEMBL
      C9JVJ9
      Conserved Domains (1) summary
      cl26863
      Location:6336
      Sugar_tr; Sugar (and other) transporter
    2. XM_024446655.2XP_024302423.1  putative transporter SVOPL isoform X1

      Conserved Domains (1) summary
      cl26863
      Location:2397
      Sugar_tr; Sugar (and other) transporter
    3. XM_017011748.2XP_016867237.1  putative transporter SVOPL isoform X3

      UniProtKB/TrEMBL
      C9JVJ9
      Conserved Domains (1) summary
      cl26863
      Location:6336
      Sugar_tr; Sugar (and other) transporter
    4. XM_047419888.1XP_047275844.1  putative transporter SVOPL isoform X4

    5. XM_017011747.2XP_016867236.1  putative transporter SVOPL isoform X3

      UniProtKB/TrEMBL
      C9JVJ9
      Conserved Domains (1) summary
      cl26863
      Location:6336
      Sugar_tr; Sugar (and other) transporter
    6. XM_047419887.1XP_047275843.1  putative transporter SVOPL isoform X2

    7. XM_024446654.2XP_024302422.1  putative transporter SVOPL isoform X1

      Conserved Domains (1) summary
      cl26863
      Location:2397
      Sugar_tr; Sugar (and other) transporter

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      139903966..140013811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357251.1XP_054213226.1  putative transporter SVOPL isoform X3

      UniProtKB/TrEMBL
      C9JVJ9
    2. XM_054357248.1XP_054213223.1  putative transporter SVOPL isoform X1

    3. XM_054357252.1XP_054213227.1  putative transporter SVOPL isoform X3

      UniProtKB/TrEMBL
      C9JVJ9
    4. XM_054357253.1XP_054213228.1  putative transporter SVOPL isoform X4

    5. XM_054357250.1XP_054213225.1  putative transporter SVOPL isoform X3

      UniProtKB/TrEMBL
      C9JVJ9
    6. XM_054357247.1XP_054213222.1  putative transporter SVOPL isoform X1

    7. XM_054357249.1XP_054213224.1  putative transporter SVOPL isoform X2