Tmsb4x thymosin, beta 4, X chromosome [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmsb4xprovided by MGI
Official Full Name: thymosin, beta 4, X chromosomeprovided by MGI
Primary source: MGI:MGI:99510
See related: Ensembl:ENSMUSG00000049775 AllianceGenome:MGI:99510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tb4; Ptmb4; Tbeta4
Summary: Predicted to enable actin monomer binding activity; enzyme binding activity; and protein sequestering activity. Acts upstream of or within regulation of cell migration. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; heart and pericardium; and tooth. Orthologous to several human genes including TMSB4X (thymosin beta 4 X-linked). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 1135.4), CNS E18 (RPKM 702.7) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F5; X 78.28 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (165990089..165996475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (167207093..167213479, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated Tbeta4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice.
Title: Upregulated Tβ4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice.
Thymosin beta4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
Title: Thymosin β4 preserves vascular smooth muscle phenotype in atherosclerosis via regulation of low density lipoprotein related protein 1 (LRP1).
Mechanism of thymosin beta4 in ameliorating liver fibrosis via the MAPK/NF-kappaB pathway.
Title: Mechanism of thymosin β4 in ameliorating liver fibrosis via the MAPK/NF-κB pathway.
Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model.
Title: Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model.
Thymosin beta4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets.
Title: Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets.
Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia.
Title: Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia.
Thymosin beta4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation.
Title: Thymosin β4 Suppresses LPS-Induced Murine Lung Fibrosis by Attenuating Oxidative Injury and Alleviating Inflammation.
Thymosin beta4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-kappaB signaling axis in APP/PS1 mice.
Title: Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice.
Discovery of thymosin beta4 as a human exerkine and growth factor.
Title: Discovery of thymosin β4 as a human exerkine and growth factor.
Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H2O2 production-thymosin beta-4 gene expression.
Title: Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H(2)O(2) production-thymosin beta-4 gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC290270P5 (e-PCR)
- UniSTS:272420

TMSB4X (e-PCR)
- UniSTS:506515

Tmsb4x (e-PCR), detects polymorphism
- UniSTS:528060

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IEA Inferred from Electronic Annotation more info
enables protein sequestering activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle G1/S phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hematopoietic stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell differentiation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of smooth muscle cell migration	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of actin monomers	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thymosin beta-4

Names: prothymosin beta 4; t beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.